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© 1996 Oxford University Press

research-article

CARCINOGENESIS: Bilioenterostomy enhances biliary carcinogenesis in hamsters

Yoshito Ikematsu 1, Tsutomu Tomioka, Shizuo Yamanaka, Yoshitsugu Tajima, Tsukasa Tsunoda 2 and Takashi Kanematsu

1The Second Department of Surgery, Nagasaki University School of Medicine 1-7-1 Sakamoto, Nagasaki 852
2Department of Gastroenterological Surgery, Kawasaki Medical School 577 Matsushima, Kawasaki 701-01, Japan

1To whom correspondence should be addressed

The aim of this study was to examine whether the type of bilioenterostomy enhances biliary carcinogenesis in the hamster model. Syrian hamsters were divided into the following groups; simple laparotomy (control group), cholecystoduodenostomy with dissection of the extrahepatic bile duct on the distal end of the common duct (CDDB group) and cholecystoileostomy with dissection of the extrahepatic bile duct on the distal end of the common duct (CIDB group). Following these procedures, all hamsters received N-nitrosobis(2-oxopropyl)amine. The diameter of the extrahepatic bile duct and plasma levels of cholecystokinin (CCK) were measured and the number of neoplastic lesions was counted microscopically. Proliferative effect of the procedures on the biliary epithelium was examined by proliferative cell nuclear antigen. In the CDDB group the extrahepatic bile duct was significantly dilated and carcinogenesis of the gall-bladder and extrahepatic bile ducts was enhanced. In the CIDB group the CCK bioactivity was stimulated and intrahepatic biliary duct, but not gall bladder and extrahepatic bile duct, carcinogenesis was promoted more than that observed in the CDDB group. Proliferation of the biliary duct epithelium was enhanced in both the CDDB and CIDB groups. Cholecystoduodenostomy enhanced intra- and extrahepatic bile duct carcinoma, whereas cholecystoileostomy promoted only intrahepatic bile duct carcinoma. Some factors in the intestinal juice seem to play a role in the promotion of biliary tract carcinoma.


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 CarcinogenesisHome page
T. Kitajima, Y. Tajima, S. Matsuzaki, T. Kuroki, K. Fukuda, and T. Kanematsu
Acceleration of spontaneous biliary carcinogenesis in hamsters by bilioenterostomy
Carcinogenesis, January 1, 2003; 24(1): 133 - 137.
[Abstract] [Full Text] [PDF]


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