Carcinogenesis, Vol 18, 127-135, Copyright © 1997 by Oxford University Press
LV Rodriguez, HA Dunsford, M Steinberg, KK Chaloupka, L Zhu, S Safe, JE Womack and LS Goldstein
The present study determined tumorigenicity, tumor classification and DNA
damage induced in infant mice by benzo[a]pyrene (B[a]P) or Manufactured Gas
Plant (MGP) residues after a single exposure. Male and female B6C3F1 mice
were exposed to B[a]P or MGP residue from a single environmental site
(MGP-4) and males were also exposed to MGP residue composite from seven
different sites (MGP-M7). At 26, 39 and 52 weeks after exposure
tumorigenesis was assessed in lung, forestomach and liver. Formation and
persistence of DNA adducts were quantified by 32P- postlabeling. Exposure
of males to B[a]P induced liver tumors in a dose and time dependent manner.
MGP induced more advanced tumors than B[a]P. Only a single liver tumor was
found in MGP-4 treated females. No forestomach and few pulmonary adenomas
were induced in males or females. MGP-4, MGP-M7 or B[a]P induced DNA
adducts in males and females. Adducts in liver, lung and forestomach peaked
on different days and decreased at different rates. At 24 h post-exposure,
no significant differences in initial DNA adduct levels occurred in males
and females exposed to MGP-4 or B[a]P. Lack of DNA damage (adducted DNA)
did not account for non-responsiveness of lung and forestomach in B6C3F1
genders as well as in liver in females. MGP tumorigenicity could not be
accounted for solely by B[a]P content nor did it reflect additivity of
B[a]P and other carcinogenic polycyclic aromatic hydrocarbons (PAHs) in
MGP. Synergy among MGP-PAHs, presence of unidentified carcinogens and/or
promoters in MGP may account for MGP potency. The B6C3F1 infant male model
is a convenient and rapid assay for assessing MGP liver tumorigenicity and
potency.
ARTICLES
Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice
University of Texas M.D. Anderson Cancer Center, Department of Molecular Pathology, Houston 77030, USA.
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