Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Korkola, J. E.
Right arrow Articles by Archer, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Korkola, J. E.
Right arrow Articles by Archer, M. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol 18, 53-57, Copyright © 1997 by Oxford University Press

ARTICLES

Resistance to chemically-induced mammary tumors in Copenhagen X nude- derived F2 athymic rats: evidence that T-cell immunity is not involved in Copenhagen resistance

JE Korkola, GA Wood and MC Archer
Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Canada.

Resistance to chemically-induced mammary tumors in the Copenhagen rat is well defined, but the mechanism of resistance has yet to be determined. We have tested whether or not Copenhagen rat resistance is dependent on T-cells, since several lines of evidence supported an involvement of the immune system. We crossed Copenhagen rats with an athymic nude rat to produce F1s, that were interbred to produce F2 animals, some of which were athymic with partial Copenhagen rat background. A comparison of the mammary tumor incidences between the nude athymic F2 animals and their non-nude littermates allowed us to determine what role, if any, T-cells played in resistance. Following treatment with N-methyl-N-nitrosourea, we observed no difference in the tumor incidences between the two groups. Furthermore, the mammary tumor incidences in the F2 nude and non-nude animals was almost zero. These results indicate that T-cells are not involved in Cop resistance, and that nude rats are resistant to N-methyl-N-nitrosourea-induced mammary tumorigenesis.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
K. M. Gering, J. A.M. Marx, K. Lennartz, C. Fischer, M. F. Rajewsky, and A. Kindler-Rohrborn
The Interaction Mode of Premalignant Schwann and Immune Effector Cells during Chemically Induced Carcinogenesis in the Rat Peripheral Nervous System Is Strongly Influenced by Genetic Background.
Cancer Res., May 1, 2006; 66(9): 4708 - 4714.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
K. A. Gould, M. Tochacek, B. S. Schaffer, T. M. Reindl, C. R. Murrin, C. M. Lachel, E. A. VanderWoude, K. L. Pennington, L. A. Flood, K. K. Bynote, et al.
Genetic Determination of Susceptibility to Estrogen-Induced Mammary Cancer in the ACI Rat: Mapping of Emca1 and Emca2 to Chromosomes 5 and 18
Genetics, December 1, 2004; 168(4): 2113 - 2125.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
G. A. Wood, J. E. Korkola, and M. C. Archer
Tissue-specific resistance to cancer development in the rat: phenotypes of tumor-modifier genes
Carcinogenesis, January 1, 2002; 23(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
G. A. Wood, J. E. Korkola, and M. C. Archer
Resistance of Copenhagen rats to hepatocarcinogenesis does not involve T-cell immunity
Carcinogenesis, February 1, 2001; 22(2): 357 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Kindler-Röhrborn, A. B. Kind, B. U. Koelsch, C. Fischer, and M. F. Rajewsky
Suppression of Ethylnitrosourea-induced Schwannoma Development Involves Elimination of neu/erbB-2 Mutant Premalignant Cells in the Resistant BDIV Rat Strain
Cancer Res., September 1, 2000; 60(17): 4756 - 4760.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
J. E. Korkola and M. C. Archer
Resistance to mammary tumorigenesis in Copenhagen rats is associated with the loss of preneoplastic lesions
Carcinogenesis, February 1, 1999; 20(2): 221 - 227.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.