Carcinogenesis, Vol 18, 9-13, Copyright © 1997 by Oxford University Press
K Hemminki, H Rajaniemi, M Koskinen and J Hansson
Tamoxifen-induced DNA adducts were searched in leucocyte DNA from breast
cancer patients. Total white blood cell DNA from tamoxifen- treated and
control patients was analysed by 32P-postlabelling using HPLC-radioactivity
detection. Rat liver DNA was used as a positive standard. In blinded
analysis four of the six treated patients showed DNA adducts; none of the
five controls were positive. The identity of fraction as a tamoxifen adduct
was confirmed by using different chromatographic systems, each with spiked
rat liver samples. The level of adducts in the treated patients was 5.5
adducts/10(9) nucleotides as compared to an apparent level of 1.9/10(9) in
the controls.
ARTICLES
Tamoxifen-induced DNA adducts in leucocytes of breast cancer patients
Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.
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