Carcinogenesis, Vol 18, 1917-1920, Copyright © 1997 by Oxford University Press
G Manenti, L De Gregorio, S Pilotti, FS Falvella, M Incarbone, F Ravagnani, MA Pierotti and TA Dragani
The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a
major locus affecting inherited predisposition to lung cancer in mice
prompted us to test the homologous human region (12p12) for association
with lung adenocarcinoma, by a population-based study. We genotyped 213
lung adenocarcinoma patients and 219 healthy blood donor subjects for five
polymorphic markers mapping in the putative region of interest. Three
marker polymorphisms, located in a region spanning approximately 700 kb,
were significantly associated with lung adenocarcinoma risk. Furthermore,
polymorphisms in KRAS2 and PTHLH loci were also associated with tumor
prognosis. These results suggest the existence of a human Pas1 homologous
locus on chromosome 12p12.
ARTICLES
Association of chromosome 12p genetic polymorphisms with lung adenocarcinoma risk and prognosis
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
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