Carcinogenesis, Vol 18, 2307-2311, Copyright © 1997 by Oxford University Press
M Esteller, A Garcia, JM Martinez-Palones, J Xercavins and J Reventos
We describe here a case-control study to identify associations between
polymorphisms at the methylenetetrahydrofolate reductase (MTHFR) and
cytochrome P-450 1A1 (CYP1A1) genes and susceptibility to endometrial
cancer. Accordingly, genotype frequencies in 80 endometrial carcinoma
patients were compared with frequencies in 60 controls. DNA analysis
suggest a significantly increased endometrial cancer risk with an alanine
to valine substitution at nucleotide 677 of MTHFR gene with an odds ratio
of 2.8 (95% confidence interval: 1.36-6.14, P = 0.002). Moreover, the
tumors from patients with the valine allele were more undifferentiated (P =
0.03). On the other hand, a recently described mutation in exon 7 of CYP1A1
gene (threonine exchanged to asparagine in codon 461) showed a strong
association with endometrial cancer risk with an odds ratio of 6.36 (95%
confidence interval: 1.99-26.5, P = 0.0004). Thus, this study suggests that
polymorphisms at MTHFR and a novel CYP1A1 variant could influence
susceptibility to endometrial cancer, although larger sample sizes would be
required to corroborate these findings.
ARTICLES
Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility
Unitat de Recerca Biomedica, Centre d'Investigacions en Bioquimica i Biologia Molecular Vall d'Hebron, Barcelona, Spain.
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