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Carcinogenesis, Vol 18, 2319-2325, Copyright © 1997 by Oxford University Press

ARTICLES

p53-dependent response in UV-induced transformation

W Zhang, X Zhang, H Zhu and S Chen
Department of Chemical Biology, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA.

Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.
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