Carcinogenesis, Vol 18, 2361-2365, Copyright © 1997 by Oxford University Press
GY Yang, Z Liu, DN Seril, J Liao, W Ding, S Kim, F Bondoc and CS Yang
The present study investigated the inhibitory activity against lung
tumorigenesis by a group of characteristic black tea polyphenols,
theaflavins. In a short-term study, female A/J mice were treated with a
single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; 103
mg/kg b.w., i.p.) on day 0, and 0.1 and 0.3% theaflavins were administered
as the sole source of drinking fluid starting 24 h after NNK treatment. The
proliferation index of the lung tissues was measured by the incorporation
of bromodeoxyuridine (BrdU) immunohistochemically. The highest NNK-induced
proliferation rate of bronchiolar cells, observed on day 5, was
significantly decreased by 0.3% theaflavins (proliferation index, 1.51 +/-
0.08 versus 2.35 +/- 0.16). In a long- term lung tumorigenesis study,
pulmonary adenomas were observed in 100% (30/30) of the mice at week 16
after NNK treatment. Administration of theaflavins (0.1%) as the sole
source of drinking fluid, starting 2 days after the NNK treatment until the
termination of the experiment, significantly reduced the tumor multiplicity
and volume by 23% (8.5 +/- 0.6 versus 6.5 +/- 0.6 tumors/mouse) and 34%
(0.08 versus 0.05 mm3 per tumor), respectively. The proliferation index in
lung adenomas was also significantly inhibited by theaflavins. The present
work demonstrates the inhibitory action of theaflavins against NNK-induced
pulmonary hyperproliferation and tumorigenesis.
ARTICLES
Black tea constituents, theaflavins, inhibit 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice
Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855-0789, USA.
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