Carcinogenesis, Vol 18, 2453-2455, Copyright © 1997 by Oxford University Press
HD Riley, J Macnab, TJ Farrell and K Cohn
We have performed differential display comparing gene expression from cell
lines derived from human colorectal tumors. The cell lines were selected
for study based on their ability to form metastases following injection
into athymic mice. One gene which was expressed exclusively by the
metastatic lines was identified as human acylphosphatase (e.c. 3.6.1.7,
acylphosphate phosphohydrolase). The expression of this gene was confirmed
by RT-PCR using gene-specific primers. This gene product catalyzes the
hydrolysis of phosphorylated intermediates of Na+/K(+)- ATPase and of
Ca(2+)-ATPases of mammalian cells. Changes in the activity of the
Na+/K(+)-ATPase pump, regulated by acylphosphatase, have been previously
reported in chemically-induced colonic tumors. The differential expression
of this gene in the human metastatic colorectal lines suggests it may be
involved in the metastatic phenotype.
ARTICLES
The expression of acylphosphatase is associated with the metastatic phenotype in human colorectal tumors
Research & Development Service, VA Medical & Regional Office Center, White River Junction, VT 05009, USA.
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