Carcinogenesis, Vol 18, 345-350, Copyright © 1997 by Oxford University Press
K Hemminki, C Dickey, S Karlsson, D Bell, Y Hsu, WY Tsai, LA Mooney, K Savela and FP Perera
Levels of aromatic DNA adducts in foundry workers and controls were
followed at four annual samplings. During this time exposure to polycyclic
aromatic hydrocarbons (PAH) decreased and the level of DNA adducts
decreased accordingly. In the total group exposure was related to the level
of adducts. Adduct levels correlated with urinary 1- hydroxypyrene
(LOGU1OH), air benzo[a]pyrene, weekly working hours and daily cigarette
consumption. In a multivariate model 1-hydroxypyrene had a consistent
effect. Neither glutathione transferase M1 (GSTM1) nor cytochrome P450 1A1
(CYP1A1) genotypes had clear effects. Yet the individuals lacking GSTM1 had
a stronger effect of LOGU1OH and some effect by other sources of PAH, such
as charcoal broiled food, although all these variables were not significant
in the multivariate model. The rare individuals with a CYP1A1 polymorphism
MspI containing an amino acid change at isoleucine had an increased level
of adducts. The results showed that the postlabelling method used was able
to detect an increase in aromatic DNA adducts in leukocytes when exposure
to benzo[a]pyrene in air was approximately 5 ng/m3. At such low levels
smoking and charcoal broiled food may be important contributors to adducts.
ARTICLES
Aromatic DNA adducts in foundry workers in relation to exposure, life style and CYP1A1 and glutathione transferase M1 genotype
Department of Biosciences, Karolinska Institute, Novum, Huddinge, Sweden.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Agudo, M. Peluso, N. Sala, G. Capella, A. Munnia, S. Piro, F. Marin, R. Ibanez, P. Amiano, M.J. Tormo, et al. Aromatic DNA adducts and polymorphisms in metabolic genes in healthy adults: findings from the EPIC-Spain cohort Carcinogenesis, June 1, 2009; 30(6): 968 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vineis and F. Perera Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 547 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vineis and F. Perera Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1954 - 1965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Masson, L. Sharp, S. C. Cotton, and J. Little Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review Am. J. Epidemiol., May 15, 2005; 161(10): 901 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Georgiadis, J. Topinka, D. Vlachodimitropoulos, M. Stoikidou, M. Gioka, G. Stephanou, H. Autrup, N. A. Demopoulos, K. Katsouyanni, R. Sram, et al. Interactions between CYP1A1 polymorphisms and exposure to environmental tobacco smoke in the modulation of lymphocyte bulky DNA adducts and chromosomal aberrations Carcinogenesis, January 1, 2005; 26(1): 93 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. A. BRANDT and W. P. WATSON Monitoring Human Occupational and Environmental Exposures to Polycyclic Aromatic Compounds Ann. Hyg., July 1, 2003; 47(5): 349 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R R W Gaertner and G P Theriault Risk of bladder cancer in foundry workers: a meta-analysis Occup. Environ. Med., October 1, 2002; 59(10): 655 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Marczynski, H.-P. Rihs, B. Rossbach, J. Holzer, J. Angerer, M. Scherenberg, G. Hoffmann, T. Bruning, and M. Wilhelm Analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms Carcinogenesis, February 1, 2002; 23(2): 273 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Firozi, M. L. Bondy, A. A. Sahin, P. Chang, F. Lukmanji, E. S. Singletary, M. M. Hassan, and D. Li Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer Carcinogenesis, February 1, 2002; 23(2): 301 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Peluso, M. Ceppi, A. Munnia, R. Puntoni, and S. Parodi Analysis of 13 32P-DNA Postlabeling Studies on Occupational Cohorts Exposed to Air Pollution Am. J. Epidemiol., March 15, 2001; 153(6): 546 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Nerurkar, L. Okinaka, C. Aoki, A. Seifried, A. Lum-Jones, L. R. Wilkens, and L. Le Marchand CYP1A1, GSTM1, and GSTP1 Genetic Polymorphisms and Urinary 1-Hydroxypyrene Excretion in Non-Occupationally Exposed Individuals Cancer Epidemiol. Biomarkers Prev., October 1, 2000; 9(10): 1119 - 1122. [Abstract] [Full Text]
|
|
|
|
|
|
M. Rojas, I. Cascorbi, K. Alexandrov, E. Kriek, G. Auburtin, L. Mayer, A. Kopp-Schneider, I. Roots, and H. Bartsch Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism Carcinogenesis, January 1, 2000; 21(1): 35 - 41. [Abstract] [Full Text] [PDF]
|
|