Carcinogenesis, Vol 18, 377-381, Copyright © 1997 by Oxford University Press
DJ Kim, BS Han, B Ahn, R Hasegawa, T Shirai, N Ito and H Tsuda
The modification potential of indole-3-carbinol (I3C), a naturally
occurring compound found in cruciferous vegetables, on neoplastic
development was assessed using a rat medium-term multiorgan carcinogenesis
model. One-hundred male Sprague-Dawley (SD) rats were randomly divided into
three groups and sequentially treated with diethylnitrosamine (DEN; 100
mg/kg b.w., a single i.p.), N-methyl-N- nitrosourea (MNU; 20 mg/kg b.w.,
four times i.p., at days 5, 8, 11 and 14), and
dihydroxy-di-N-propyl-nitrosamine (DHPN; 0.1% in the drinking water during
weeks 1 and 3) (DMD treatment; groups 1 and 2) or the vehicles alone (group
3) in the first 3-week initiation period. Animals of groups 1 and 3 were
then given diet containing 0.25% I3C from week 4 until week 24, followed by
a return to basal diet for 28 weeks, and subgroups were killed at weeks 24
and 52. I3C caused significant increases in both number (no./cm2) and area
(mm2/cm2) of glutathione S- transferase placental form (GST-P)-positive
liver cell foci assessed at week 24 of the experiment (P<0.01, 0.001).
The incidence of hepatocellular adenomas in the DMD and I3C group at week
52 showed a tendency for elevation as compared to the DMD alone group, but
this was not statistically significant. The thyroid gland tumour incidences
in the DMD and I3C groups were significantly increased compared with the
DMD alone group values at week 52 (P<0.01). In conclusion, I3C enhanced
liver and thyroid gland neoplastic development when given during the
promotion stage in the present rat medium-term multiorgan carcinogenesis
model.
ARTICLES
Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model
Chemotherapy Division, National Cancer Centre Research Institute, Chuo- ku, Tokyo, Japan.
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