Carcinogenesis, Vol 18, 399-405, Copyright © 1997 by Oxford University Press
A Hartwig, UD Groblinghoff, D Beyersmann, AT Natarajan, R Filon and LH Mullenders
Even though epidemiological studies have identified arsenic compounds as
carcinogenic to humans, they are not mutagenic in bacterial and mammalian
test systems. However, they increase the mutagenicity and clastogenicity in
combination with other DNA damaging agents and there are indications of
inhibition of DNA repair processes. We investigated the effect of
arsenic(III) on nucleotide excision repair (NER) after UV irradiation in
human fibroblasts in detail by using two repair- proficient and one partly
repair-deficient xeroderma pigmentosum group C human fibroblast cell lines.
The results show that two steps of NER are affected by arsenite. Most
severely, the incision frequency is reduced at concentrations as low as 2.5
microM arsenic(III); at higher, cytotoxic concentrations, the ligation of
repair patches is also impaired. Furthermore, our results indicate that
both the global genome repair pathway and the transcription-coupled repair
pathway are affected by arsenite. Repair inhibition may well explain the
potentiation of genotoxic effects by arsenic in combination with other DNA
damaging agents and may thus be of high relevance for the carcinogenic
action of arsenic compounds.
ARTICLES
Interaction of arsenic(III) with nucleotide excision repair in UV- irradiated human fibroblasts
University of Bremen, Department of Biology and Chemistry, Germany.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Wang, D. C. Wolf, B. Sen, G. W. Knapp, S. D. Holladay, W. R. Huckle, T. Caceci, and J. L. Robertson Dimethylarsinic Acid in Drinking Water Changed the Morphology of Urinary Bladder but Not the Expression of DNA Repair Genes of Bladder Transitional Epithelium in F344 Rats Toxicol Pathol, June 1, 2009; 37(4): 425 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Liu, J. A. Kramer, Y. Hu, J. M. Schmidt, J. Jiang, and A. G. E. Wilson Development of a High-Throughput Human HepG2 Dual Luciferase Assay for Detection of Metabolically Activated Hepatotoxicants and Genotoxicants International Journal of Toxicology, May 1, 2009; 28(3): 162 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. V. Breton, W. Zhou, M. L. Kile, E.A. Houseman, Q. Quamruzzaman, M. Rahman, G. Mahiuddin, and D. C. Christiani Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes Carcinogenesis, July 1, 2007; 28(7): 1520 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Hays, D. Srinivasan, M. L. Witten, D. E. Carter, and R. C. Lantz Arsenic and Cigarette Smoke Synergistically Increase DNA Oxidation in the Lung Toxicol Pathol, June 1, 2006; 34(4): 396 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Li, J.-C. Lin, and J.-L. Yang ERK Activation in Arsenite-Treated G1-Enriched CL3 Cells Contributes to Survival, DNA Repair Inhibition, and Micronucleus Formation Toxicol. Sci., January 1, 2006; 89(1): 164 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Dopp, L. M. Hartmann, U. von Recklinghausen, A. M. Florea, S. Rabieh, U. Zimmermann, B. Shokouhi, S. Yadav, A. V. Hirner, and A. W. Rettenmeier Forced Uptake of Trivalent and Pentavalent Methylated and Inorganic Arsenic and Its Cyto-/genotoxicity in Fibroblasts and Hepatoma Cells Toxicol. Sci., September 1, 2005; 87(1): 46 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.D. Evans, K. LaDow, B.L. Schumann, R.E. Savage Jr, J. Caruso, A. Vonderheide, P. Succop, and G. Talaska Effect of arsenic on benzo[a]pyrene DNA adduct levels in mouse skin and lung Carcinogenesis, April 1, 2004; 25(4): 493 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Danaee, H. H. Nelson, H. Liber, J. B. Little, and K. T. Kelsey Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells Mutagenesis, March 1, 2004; 19(2): 143 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Tchounwou, A. K. Patlolla, and J. A. Centeno Invited Reviews: Carcinogenic and Systemic Health Effects Associated with Arsenic Exposure--A Critical Review Toxicol Pathol, October 1, 2003; 31(6): 575 - 588. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Li, M. Gorospe, J. Barnes, and Y. Liu Tumor Promoter Arsenite Stimulates Histone H3 Phosphoacetylation of Proto-oncogenes c-fos and c-jun Chromatin in Human Diploid Fibroblasts J. Biol. Chem., April 4, 2003; 278(15): 13183 - 13191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Hamadeh, K. J. Trouba, R. P. Amin, C. A. Afshari, and D. Germolec Coordination of Altered DNA Repair and Damage Pathways in Arsenite-Exposed Keratinocytes Toxicol. Sci., October 1, 2002; 69(2): 306 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sciandrello, R. Barbaro, F. Caradonna, and G. Barbata Early induction of genetic instability and apoptosis by arsenic in cultured Chinese hamster cells Mutagenesis, March 1, 2002; 17(2): 99 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.T. Bau, J.R. Gurr, and K.Y. Jan Nitric oxide is involved in arsenite inhibition of pyrimidine dimer excision Carcinogenesis, May 1, 2001; 22(5): 709 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-H. Yih and T.-C. Lee Arsenite Induces p53 Accumulation through an ATM-dependent Pathway in Human Fibroblasts Cancer Res., November 1, 2000; 60(22): 6346 - 6352. [Abstract] [Full Text]
|
|
|
|
|
|
M. Asmuss, L. H.F. Mullenders, A. Eker, and A. Hartwig Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair Carcinogenesis, November 1, 2000; 21(11): 2097 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Boonchai, M. Walsh, M. Cummings, and G. Chenevix-Trench Expression of p53 in Arsenic-Related and Sporadic Basal Cell Carcinoma Arch Dermatol, February 1, 2000; 136(2): 195 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Krueger, L. H.F. Mullenders, and A. Hartwig Nickel(II) increases the sensitivity of V79 Chinese hamster cells towards cisplatin and transplatin by interference with distinct steps of DNA repair Carcinogenesis, July 1, 1999; 20(7): 1177 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Rossman and Z. Wang Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis Carcinogenesis, February 1, 1999; 20(2): 311 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Chen, J. L. Martindale, N. J. Holbrook, and Y. Liu Tumor Promoter Arsenite Activates Extracellular Signal-Regulated Kinase through a Signaling Pathway Mediated by Epidermal Growth Factor Receptor and Shc Mol. Cell. Biol., September 1, 1998; 18(9): 5178 - 5188. [Abstract] [Full Text]
|
|