Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (103)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wood, R. D.
Right arrow Articles by Shivji, M. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wood, R. D.
Right arrow Articles by Shivji, M. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol 18, 605-610, Copyright © 1997 by Oxford University Press

REVIEWS

Which DNA polymerases are used for DNA-repair in eukaryotes?

RD Wood and MK Shivji
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK.

There are five well-characterized nuclear DNA polymerases in eukaryotes (DNA polymerases alpha, beta, delta, epsilon and zeta) and this short review summarizes our current knowledge concerning the participation of each in DNA-repair. The three major DNA excision-repair pathways involve a DNA synthesis step that replaces altered bases or nucleotides removed during repair. Base excision-repair removes many modified bases and abasic sites, and in mammalian cells this mainly involves DNA polymerase beta. An alternative means for completion of base excision- repair, involving DNA polymerases delta or epsilon, may also operate and be even more important in yeast. Nucleotide excision-repair uses DNA polymerases delta or epsilon to resynthesize the bases removed during repair of pyrimidine dimers and other bulky adducts in DNA. Similarly, mismatch-repair of replication errors appears to involve DNA polymerases delta or epsilon. DNA polymerase alpha is required for semi- conservative replication of DNA but not for repair of DNA. A more recently discovered enzyme, DNA polymerase zeta, appears to be involved in the bypass of damage, without excision, and occurs during DNA replication of a damaged template.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J AndrolHome page
M. Hamzeh and B. Robaire
Effect of Testosterone on Epithelial Cell Proliferation in the Regressed Rat Epididymis
J Androl, March 1, 2009; 30(2): 200 - 212.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
C. A. Picut, C. L. Swanson, K. L. Scully, V. C. Roseman, R. F. Parker, and A. K. Remick
Ovarian Follicle Counts Using Proliferating Cell Nuclear Antigen (PCNA) and Semi-Automated Image Analysis in Rats
Toxicol Pathol, July 1, 2008; 36(5): 674 - 679.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
M. K. Poxleitner, S. C. Dawson, and W. Z. Cande
Cell Cycle Synchrony in Giardia intestinalis Cultures Achieved by Using Nocodazole and Aphidicolin
Eukaryot. Cell, April 1, 2008; 7(4): 569 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Matsumoto, K. Yaginuma, A. Igarashi, M. Imura, M. Hasegawa, K. Iwabuchi, T. Date, T. Mori, K. Ishizaki, K. Yamashita, et al.
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells
J. Cell Sci., March 15, 2007; 120(6): 1104 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
L. Muskhelishvili, S. K. Wingard, and J. R. Latendresse
Proliferating Cell Nuclear Antigen--A Marker for Ovarian Follicle Counts
Toxicol Pathol, April 1, 2005; 33(3): 365 - 368.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
L. Muskhelishvili, J. R. Latendresse, R. L. Kodell, and E. B. Henderson
Evaluation of Cell Proliferation in Rat Tissues with BrdU, PCNA, Ki-67(MIB-5) Immunohistochemistry and In Situ Hybridization for Histone mRNA
J. Histochem. Cytochem., December 1, 2003; 51(12): 1681 - 1688.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. L. DeBiasi, P. Clarke, S. Meintzer, R. Jotte, B. K. Kleinschmidt-Demasters, G. L. Johnson, and K. L. Tyler
Reovirus-Induced Alteration in Expression of Apoptosis and DNA Repair Genes with Potential Roles in Viral Pathogenesis
J. Virol., August 15, 2003; 77(16): 8934 - 8947.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Zhang, X. Wu, D. Guo, O. Rechkoblit, J.-S. Taylor, N. E. Geacintov, and Z. Wang
Lesion Bypass Activities of Human DNA Polymerase {micro}
J. Biol. Chem., November 8, 2002; 277(46): 44582 - 44587.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Iams, E. D. Larson, and J. T. Drummond
DNA Template Requirements for Human Mismatch Repair in Vitro
J. Biol. Chem., August 16, 2002; 277(34): 30805 - 30814.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. H. Wu, J. H. Chang, and B. Y.M. Yung
Resistance to UV-induced cell-killing in nucleophosmin/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin/B23 over-expression
Carcinogenesis, January 1, 2002; 23(1): 93 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
A. Li, D. Schuermann, F. Gallego, I. Kovalchuk, and B. Tinland
Repair of Damaged DNA by Arabidopsis Cell Extract
PLANT CELL, January 1, 2002; 14(1): 263 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Zhang, X. Wu, F. Yuan, Z. Xie, and Z. Wang
Highly Frequent Frameshift DNA Synthesis by Human DNA Polymerase {micro}
Mol. Cell. Biol., December 1, 2001; 21(23): 7995 - 8006.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Y.-H. He, M. Wu, M. Kobune, Y. Xu, M. R. Kelley, and W. J. Martin II
Expression of Yeast Apurinic/Apyrimidinic Endonuclease (APN1) Protects Lung Epithelial Cells From Bleomycin Toxicity
Am. J. Respir. Cell Mol. Biol., December 1, 2001; 25(6): 692 - 698.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y. CANITROT, J.-S. HOFFMANN, P. CALSOU, H. HAYAKAWA, B. SALLES, and C. CAZAUX
Nucleotide excision repair DNA synthesis by excess DNA polymerase {beta}: a potential source of genetic instability in cancer cells
FASEB J, September 1, 2000; 14(12): 1765 - 1774.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J.-S. Liu, S.-R. Kuo, M. M. McHugh, T. A. Beerman, and T. Melendy
Adozelesin Triggers DNA Damage Response Pathways and Arrests SV40 DNA Replication through Replication Protein A Inactivation
J. Biol. Chem., January 14, 2000; 275(2): 1391 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
T. Lindahl and R. D. Wood
Quality Control by DNA Repair
Science, December 3, 1999; 286(5446): 1897 - 1905.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
M. Schiltz, X. X. Cui, Y.-P. Lu, H. Yagi, D. M. Jerina, M. Z. Zdzienicka, R. L. Chang, A. H. Conney, and S.-J.C. Wei
Characterization of the mutational profile of (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene at the hypoxanthine (guanine) phosphoribosyltransferase gene in repair-deficient Chinese hamster V-H1 cells
Carcinogenesis, December 1, 1999; 20(12): 2279 - 2286.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. E. Wilson and M. R. Lieber
Efficient Processing of DNA Ends during Yeast Nonhomologous End Joining. EVIDENCE FOR A DNA POLYMERASE beta (POL4)-DEPENDENT PATHWAY
J. Biol. Chem., August 13, 1999; 274(33): 23599 - 23609.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. J. Moreland, M. Illand, Y. T. Kim, J. Paul, and R. Brown
Modulation of Drug Resistance Mediated by Loss of Mismatch Repair by the DNA Polymerase Inhibitor Aphidicolin
Cancer Res., May 1, 1999; 59(9): 2102 - 2106.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
W. L. de Laat, N. G.J. Jaspers, and J. H.J. Hoeijmakers
Molecular mechanism of nucleotide excision repair
Genes & Dev., April 1, 1999; 13(7): 768 - 785.
[Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. I. Wu, N. Pollack, R. J. Panos, P. H. S. Sporn, and D. W. Kamp
Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure
Am J Physiol Lung Cell Mol Physiol, October 1, 1998; 275(4): L780 - L787.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
G. A. Church, A. Dasgupta, and D. W. Wilson
Herpes Simplex Virus DNA Packaging without Measurable DNA Synthesis
J. Virol., April 1, 1998; 72(4): 2745 - 2751.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Biade, R. W. Sobol, S. H. Wilson, and Y. Matsumoto
Impairment of Proliferating Cell Nuclear Antigen-dependent Apurinic/Apyrimidinic Site Repair on Linear DNA
J. Biol. Chem., January 9, 1998; 273(2): 898 - 902.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. D. Wood
Nucleotide Excision Repair in Mammalian Cells
J. Biol. Chem., September 19, 1997; 272(38): 23465 - 23468.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. R. Vance and T. E. Wilson
Uncoupling of 3'-Phosphatase and 5'-Kinase Functions in Budding Yeast. CHARACTERIZATION OF SACCHAROMYCES CEREVISIAE DNA 3'-PHOSPHATASE (TPP1)
J. Biol. Chem., April 27, 2001; 276(18): 15073 - 15081.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.