Carcinogenesis, Vol 18, 1371-1374, Copyright © 1997 by Oxford University Press
BS Reddy, R Hamid and CV Rao
Oligofructose and inulin, naturally-occurring fermentable chicory fructans,
have been shown to stimulate the growth of bifidobacteria which are
regarded as beneficial strains in the colon and inhibit colon
carcinogenesis in the laboratory animal models. The present study was
designed to determine the effect of oligofructose and inulin on the
azoxymethane (AOM)-induced preneoplastic lesions such as aberrant crypt
foci (ACF) formation in the colon of male F344 rats. At 5 weeks of age,
groups of animals were fed the AIN-76A (control) and the experimental diets
containing 10% oligofructose or inulin. At 7 weeks of age, all animals
received s.c. injection of AOM dissolved in normal saline at a dose rate of
15 mg/kg body wt, once weekly for 2 weeks. The animals were necropsied 7
weeks after the last AOM injection, and the ACF were visualized under light
microscopy in the formalin-fixed, unsectioned methylene blue-stained
colons. They were distinguished by their increased size, more prominent
epithelial cells and pericryptal space. The feeding of oligofructose or
inulin significantly inhibited the ACF formation and the crypt multiplicity
in the colon. The degree of ACF inhibition was more pronounced in animals
fed inulin than in those fed oligofructose. The findings suggest that
chicory fructan supplements inhibit ACF formation, an early preneoplastic
marker of malignant potential in the process of colon carcinogenesis.
ARTICLES
Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition
Division of Nutritional Carcinogenesis, American Health Foundation, Valhalla, NY 10595, USA.
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