Carcinogenesis, Vol 18, 1431-1433, Copyright © 1997 by Oxford University Press
JK Wiencke, MR Wrensch, R Miike, Z Zuo and KT Kelsey
Gene deletion at the glutathione S-transferase mu locus (GSTM1) has
previously been associated with increased risk for environmentally- induced
cancers (e.g. smoking-related lung cancer). In the present study we
examined the hypothesis that GSTM1 deletion is a risk factor for malignant
brain tumors in adults. We compared the prevalence of the GSTM1 homozygous
deletion polymorphism in 158 Caucasian adults with gliomas with 157
controls. Cases and controls were drawn from a large population-based
case-control study of brain cancers in six San Francisco Bay area counties.
Overall, the prevalence of the GSTM1 deletion was similar in cases (83/158;
53%) and controls (78/157; 50%). Among brain tumor cases, analysis of
variance modeling indicated a significant interaction of GSTM1 genotype and
gender associated with age at diagnosis (P = 0.02). This effect was due to
the fact that women with GSTM1 deletion were younger on average at
diagnosis than women who were GSTM1 positive (43.9 years versus 52.4 years,
respectively). Age at diagnosis among men was similar for those who were
GSTM1 deleted and GSTM1 positive (49.4 years and 47.2 years, respectively).
The younger age at diagnosis of GSTM1 null female cases compared with GSTM1
positive cases was observed in astrocytoma as well as the higher grade
tumors (e.g. glioblastoma multiforme). There was no association of GSTM1
deletion with age or gender in controls. These studies suggest that among
female cases, GSTM1 deletion may be associated with earlier age at onset.
Confirmation of these findings could provide important clues to
gene-environment interactions in the etiology of malignant brain tumors.
ARTICLES
Population-based study of glutathione S-transferase mu gene deletion in adult glioma cases and controls
Department of Epidemiology and Biostatistics, University of California San Francisco, 94143-0560, USA.
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