Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (73)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by To-Figueras, J.
Right arrow Articles by Corbella, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by To-Figueras, J.
Right arrow Articles by Corbella, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol 18, 1529-1533, Copyright © 1997 by Oxford University Press

ARTICLES

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and lung cancer risk among Northwestern Mediterraneans

J To-Figueras, M Gene, J Gomez-Catalan, MC Galan, M Fuentes, JM Ramon, M Rodamilans, E Huguet and J Corbella
Toxicology Unit, Faculty of Medicine, Hospital Clinic i Provincial de Barcelona, University of Barcelona, Catalonia, Spain.

Several polymorphic genes including those encoding for glutathione S- transferases (GST) have been reported to be involved in modifying lung cancer risk in smokers. The gene GSTM1 is frequently deleted in humans and a possible association between the null genotype and lung cancer risk is controversial. Another polymorphic gene of the same supergene family, GSTT1, is also involved in the detoxification of some environmental carcinogens. Both genes were genotyped in (a) a group of lung cancer patients (n = 160); (b) a group of healthy smokers (n = 120); (c) a group of blood donors from the general population (n = 192). All patients and controls were Northwestern Mediterranean Caucasians. The results show that the GSTM1 null genotype (GSTM1*0/GSTM1*0) was slightly over represented in the lung cancer patients (frequency of 58%; OR: 1.40, 95% CI: 0.74-2.61, referred to healthy smokers). The histological type most clearly modified was small cell carcinoma (frequency of 62.2%, OR: 1.91, CI: 0.78-4.69). The subdivision of the patients with one or two copies of the GSTM1 gene according to a GSTM1*A, GSTM1*B or GSTM1*A/B genotype (frequencies of 28.2%, 11.2%, 2.5% respectively) revealed no significant differences between the cases and both control groups. The frequency of the deleted GSTT1 genotype among the lung cancer patients (24%) was not significantly increased (OR: 1.08, CI: 0.57-2.05, referred to healthy smokers). The results showed that 14.4% of the patients presented homozygous deletion of both GSTT1 and GSTM1 (12.5% among healthy smokers) suggesting no potentiation between null genotypes for lung cancer risk.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
C. Carlsten, G. S. Sagoo, A. J. Frodsham, W. Burke, and J. P. T. Higgins
Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis
Am. J. Epidemiol., April 1, 2008; 167(7): 759 - 774.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. D. Gilliland, Y.-F. Li, H. Gong Jr., and D. Diaz-Sanchez
Glutathione S-Transferases M1 and P1 Prevent Aggravation of Allergic Responses by Secondhand Smoke
Am. J. Respir. Crit. Care Med., December 15, 2006; 174(12): 1335 - 1341.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
S Raimondi, V Paracchini, H Autrup, J. Barros-Dios, S Benhamou, P Boffetta, M. Cote, I. Dialyna, V Dolzan, R Filiberti, et al.
Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A HuGE-GSEC Review
Am. J. Epidemiol., December 1, 2006; 164(11): 1027 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
T. Kawaguchi, A. Matsumura, K. Iuchi, S. Ishikawa, H. Maeda, S. Fukai, H. Komatsu, and M. Kawahara
Second Primary Cancers in Patients with Stage III Non-Small Cell Lung Cancer Successfully Treated with Chemo-radiotherapy
Jpn. J. Clin. Oncol., January 1, 2006; 36(1): 7 - 11.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M.L. Cote, S.L.R. Kardia, A.S. Wenzlaff, S.J. Land, and A.G. Schwartz
Combinations of glutathione S-transferase genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study
Carcinogenesis, April 1, 2005; 26(4): 811 - 819.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. R. Spitz, X. Wu, and G. Mills
Integrative Epidemiology: From Risk Assessment to Outcome Prediction
J. Clin. Oncol., January 10, 2005; 23(2): 267 - 275.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. Yang, W.R. Bamlet, J.O. Ebbert, W.R. Taylor, and M. de Andrade
Glutathione pathway genes and lung cancer risk in young and old populations
Carcinogenesis, October 1, 2004; 25(10): 1935 - 1944.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
I. A. Hakim, R. B. Harris, H-H. S. Chow, M. Dean, S. Brown, and I. U. Ali
Effect of a 4-Month Tea Intervention on Oxidative DNA Damage among Heavy Smokers: Role of Glutathione S-Transferase Genotypes
Cancer Epidemiol. Biomarkers Prev., February 1, 2004; 13(2): 242 - 249.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
I. Stucker, A. Hirvonen, I. de Waziers, A. Cabelguenne, K. Mitrunen, S. Cenee, E. Koum-Besson, D. Hemon, P. Beaune, and M.-A. Loriot
Genetic polymorphisms of glutathione S-transferases as modulators of lung cancer susceptibility
Carcinogenesis, September 1, 2002; 23(9): 1475 - 1481.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Benhamou, W. J. Lee, A.-K. Alexandrie, P. Boffetta, C. Bouchardy, D. Butkiewicz, J. Brockmoller, M. L. Clapper, A. Daly, V. Dolzan, et al.
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
Carcinogenesis, August 1, 2002; 23(8): 1343 - 1350.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Garte, L. Gaspari, A.-K. Alexandrie, C. Ambrosone, H. Autrup, J. L. Autrup, H. Baranova, L. Bathum, S. Benhamou, P. Boffetta, et al.
Metabolic Gene Polymorphism Frequencies in Control Populations
Cancer Epidemiol. Biomarkers Prev., December 1, 2001; 10(12): 1239 - 1248.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. IZZOTTI, C. CARTIGLIA, J. LEWTAS, and S. DE FLORA
Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype
FASEB J, March 1, 2001; 15(3): 752 - 757.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
N. Malats, A.-M. Camus-Radon, F. Nyberg, W. Ahrens, V. Constantinescu, A. Mukeria, S. Benhamou, H. Batura-Gabryel, I. Bruske-Hohlfeld, L. Simonato, et al.
Lung Cancer Risk in Nonsmokers and GSTM1 and GSTT1 Genetic Polymorphism
Cancer Epidemiol. Biomarkers Prev., August 1, 2000; 9(8): 827 - 833.
[Abstract] [Full Text]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. S. Houlston
Glutathione S-Transferase M1 Status and Lung Cancer Risk: A Meta-Analysis
Cancer Epidemiol. Biomarkers Prev., August 1, 1999; 8(8): 675 - 682.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.