Carcinogenesis, Vol 18, 1763-1766, Copyright © 1997 by Oxford University Press
S Asami, H Manabe, J Miyake, Y Tsurudome, T Hirano, R Yamaguchi, H Itoh and H Kasai
To evaluate the effect of cigarette smoking on oxidative stress in lung
tissues, we compared the levels of a type of oxidative DNA damage, 8-
hydroxydeoxyguanosine (8-OH-dG), in tissue obtained from the central sites
of lungs from 14 current smokers, seven ex-smokers and nine non- smokers.
The mean level of 8-OH-dG in the lung tissues from smokers was 1.43-fold
higher than that of the non-smokers (the difference was statistically
significant, P = 0.0262). A positive correlation between the 8-OH-dG levels
in normal lung tissues and the Brinkman index was obtained from smokers and
ex-smokers (r = 0.525; P = 0.0134). A positive correlation was also
obtained for the 8-OH-dG levels in normal lung tissues and the number of
cigarettes smoked per day (r = 0.436; P = 0.0132). These results suggest
that oxidative DNA damage is induced in lung DNA by cigarette smoking.
ARTICLES
Cigarette smoking induces an increase in oxidative DNA damage, 8- hydroxydeoxyguanosine, in a central site of the human lung
Department of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan.
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
A. C Carr and B. Frei Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1086 - 1107. [Abstract] [Full Text] [PDF]
|
|