Carcinogenesis, Vol 19, 117-124, Copyright © 1998 by Oxford University Press
SJ Culp, DW Gaylor, WG Sheldon, LS Goldstein and FA Beland
The tumorigenicity of two coal tar mixtures was compared to that of
benzo[a]pyrene after 2 years of feeding. Mixture 1, a composite of coal tar
from seven coal gasification plant waste sites, was fed to female B6C3F1
mice (48 mice per group) for 2 years at doses of 0.0, 0.01, 0.03, 0.1, 0.3,
0.6 and 1.0%. Mixture 2, which was composed of coal tar from two of the
seven waste sites and another site having a high benzo[a]pyrene content,
was fed at doses of 0.0, 0.03, 0.1 and 0.3%. Additional groups of mice were
fed 0, 5, 25 and 100 ppm benzo[a]pyrene. The coal tar diets induced a
dose-related increase in hepatocellular adenomas and carcinomas,
alveolar/bronchiolar adenomas and carcinomas, forestomach squamous
epithelial papillomas and carcinomas, small intestine adenocarcinomas,
histiocytic sarcomas, hemangiosarcomas in multiple organs and sarcomas.
Benzo[a]pyrene treatment resulted in an increased incidence of papillomas
and/or carcinomas of the forestomach, esophagus and tongue. A comparison of
the results indicated that the benzo[a]pyrene in the coal tar diets could
be responsible for the forestomach tumors. In contrast, the lung and liver
tumors appeared to be due to other genotoxic components contained within
the coal tar mixture, while the small intestine tumors resulted from
chemically- induced cell proliferation that occurred at high doses of coal
tar.
ARTICLES
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay
National Center for Toxicological Research, Jefferson, AR 72079, USA. SCULP@NCTR.FDA.GOV
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