Carcinogenesis, Vol 19, 81-85, Copyright © 1998 by Oxford University Press
JM Kim, S Araki, DJ Kim, CB Park, N Takasuka, H Baba-Toriyama, T Ota, Z Nir, F Khachik, N Shimidzu, Y Tanaka, T Osawa, T Uraji, M Murakoshi, H Nishino and H Tsuda
The present study was carried out to examine the chemopreventive effects of
carotenoids such as fucoxanthin, lycopene and lutein as well as curcumin
and its derivative, tetrahydrocurcumin (THC), on development of putative
preneoplastic aberrant crypt foci (ACF) in colons of mice initiated with
1,2-dimethylhydrazine dihydrochloride (DMH). Influence on proliferation of
colonic crypt epithelial cells was also assessed in terms of
5-bromo-2'-deoxyuridine (BrdU) incorporation. Five-week-old B6C3F1 male
mice were divided into three groups, groups 1 and 2 being given DMH (20
mg/kg body wt, s.c.) twice a week for 3 weeks. Animals of group 1 were then
treated with one of the test compounds, lycopene (0.005% and 0.0025%) or
fucoxanthin (0.01%) in the drinking water and lutein (0.05%), curcumin
(0.5%) or THC (0.5% and 0.2%) in the diet from weeks 5-12. Group 2 served
as a carcinogen alone control and group 3 mice were given test compounds
alone. All animals were killed at week 12. Numbers of ACF/mouse in the
group 1 treated with fucoxanthin (47.1 +/- 13.7), lutein (42.6 +/- 19.6) or
0.5% THC (46.6 +/- 17.7) were significantly decreased as compared to the
control group 2 value (63.3 +/- 19.4) (P < 0.01). Numbers of aberrant
crypts (ACs)/mouse were also significantly lower after treatment with
lutein (79.9 +/- 34.7) or 0.5% THC (81.8 +/- 32.5) than in the control
group (115.1 +/- 37.1) (P < 0.01). BrdU labeling indices (LI) in mice
treated with lutein and 0.5% THC were significantly decreased in both upper
and lower half compartments of colonic crypts as compared to the controls
(P < 0.05 and 0.01, respectively), especially the upper half data
corresponding to reduction of ACs/mouse. The results thus suggest that
fucoxanthin, lutein, and THC may have potential as chemopreventive agents
against colon carcinogenesis.
ARTICLES
Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation
Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. K. Vareed, M. Kakarala, M. T. Ruffin, J. A. Crowell, D. P. Normolle, Z. Djuric, and D. E. Brenner Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects Cancer Epidemiol. Biomarkers Prev., June 1, 2008; 17(6): 1411 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-S. Huang, J.-W. Liao, and M.-L. Hu Lycopene Inhibits Experimental Metastasis of Human Hepatoma SK-Hep-1 Cells in Athymic Nude Mice J. Nutr., March 1, 2008; 138(3): 538 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zeng, F. Qiu, Y. Liu, G. Qu, and X. Yao Isolation and Identification of Phase 1 Metabolites of Demethoxycurcumin in Rats Drug Metab. Dispos., September 1, 2007; 35(9): 1564 - 1573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Li, Z. Zhang, D. L. Hill, H. Wang, and R. Zhang Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway Cancer Res., March 1, 2007; 67(5): 1988 - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Han, S.-J. Son, M. Akhalaia, A. Platonov, H.-J. Son, K.-H. Lee, Y.-S. Yun, and J.-Y. Song Modulation of Radiation-Induced Disturbances of Antioxidant Defense Systems by Ginsan Evid. Based Complement. Altern. Med., December 1, 2005; 2(4): 529 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Xu, L. Ziqing, D. Yinrun, W. Xiaoyan, and X. Jinglun Tripterygium hypoglaucum (level) Hutch induces aneuploidy of chromosome 8 in mouse bone marrow cells and sperm Mutagenesis, September 1, 2004; 19(5): 379 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Jana, P. Dikshit, A. Goswami, and N. Nukina Inhibition of Proteasomal Function by Curcumin Induces Apoptosis through Mitochondrial Pathway J. Biol. Chem., March 19, 2004; 279(12): 11680 - 11685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Asai, T. Sugawara, H. Ono, and A. Nagao BIOTRANSFORMATION OF FUCOXANTHINOL INTO AMAROUCIAXANTHIN A IN MICE AND HEPG2 CELLS: FORMATION AND CYTOTOXICITY OF FUCOXANTHIN METABOLITES Drug Metab. Dispos., February 1, 2004; 32(2): 205 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Mollersen, J. E. Paulsen, H. B. Olstorn, H. K. Knutsen, and J. Alexander Dietary retinoic acid supplementation stimulates intestinal tumour formation and growth in multiple intestinal neoplasia (Min)/+ mice Carcinogenesis, January 1, 2004; 25(1): 149 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Jackson, P. J. O'Connor, D. P. Cooper, G. P. Margison, and A. C. Povey Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine Carcinogenesis, March 1, 2003; 24(3): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Povey, A. F. Badawi, D. P. Cooper, C. N. Hall, K. L. Harrison, P. E. Jackson, N. P. Lees, P. J. O'Connor, and G. P. Margison DNA Alkylation and Repair in the Large Bowel: Animal and Human Studies J. Nutr., November 1, 2002; 132(11): 3518S - 3521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sugawara, V. Baskaran, W. Tsuzuki, and A. Nagao Brown Algae Fucoxanthin Is Hydrolyzed to Fucoxanthinol during Absorption by Caco-2 Human Intestinal Cells and Mice J. Nutr., May 1, 2002; 132(5): 946 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Palozza, S. Serini, N. Maggiano, M. Angelini, A. Boninsegna, F. Di Nicuolo, F. O. Ranelletti, and G. Calviello Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by {beta}-carotene through down-regulation of cyclin A and Bcl-2 family proteins Carcinogenesis, January 1, 2002; 23(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Anto, A. Mukhopadhyay, K. Denning, and B. B. Aggarwal Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl Carcinogenesis, January 1, 2002; 23(1): 143 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Okada, C. Wangpoengtrakul, T. Tanaka, S. Toyokuni, K. Uchida, and T. Osawa Curcumin and Especially Tetrahydrocurcumin Ameliorate Oxidative Stress-Induced Renal Injury in Mice J. Nutr., August 1, 2001; 131(8): 2090 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Inano, M. Onoda, N. Inafuku, M. Kubota, Y. Kamada, T. Osawa, H. Kobayashi, and K. Wakabayashi Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats Carcinogenesis, October 1, 2000; 21(10): 1835 - 1841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Rao and S. Agarwal Role of Antioxidant Lycopene in Cancer and Heart Disease J. Am. Coll. Nutr., October 1, 2000; 19(5): 563 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. N. Sumantran, R. Zhang, D. S. Lee, and M. S. Wicha Differential Regulation of Apoptosis in Normal versus Transformed Mammary Epithelium by Lutein and Retinoic Acid Cancer Epidemiol. Biomarkers Prev., March 1, 2000; 9(3): 257 - 263. [Abstract] [Full Text]
|
|
|
|
|
|
H. Inano, M. Onoda, N. Inafuku, M. Kubota, Y. Kamada, T. Osawa, H. Kobayashi, and K. Wakabayashi Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with {gamma}-rays Carcinogenesis, June 1, 1999; 20(6): 1011 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Dinkova-Kostova and P. Talalay Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes Carcinogenesis, May 1, 1999; 20(5): 911 - 914. [Abstract] [Full Text] [PDF]
|
|