Carcinogenesis, Vol 19, 1723-1733, Copyright © 1998 by Oxford University Press
AH Mullin, D Nataraj, JJ Ren and DA Mullin
This study investigated the frequency and pattern of mutations that arose
in lacI transgenes in lung tissues of mice exposed to 300 p.p.m. of benzene
for 6 h/day x 5 days/week for 12 weeks. The nucleotide sequence changes in
86 lacI- transgenes from lung tissues of eight benzene-exposed mice (BEM)
and 78 spontaneous lacI- transgenes from lung tissues of eight unexposed
control mice (UCM) were identified and compared. A total of 31% (27/86) of
the lacI mutations in BEM are deletions compared with 9% (7/78) deletions
in UCM. In BEM, 44% (12/27) of the deletions were longer than 10 bp,
whereas only 14% (1/7) of the deletions in UCM exceeded 10 bp in length.
Statistical tests supported the hypothesis that benzene exposure resulted
in significant increases in both the frequency and length of deletions.
Based on the lacI mutant frequency and fraction of unique mutations, lung
tissues of BEM were estimated to have a 1.8-fold increase in lacI mutation
frequency compared with lung tissues of UCM. The results presented in this
paper demonstrate that inhaled benzene is a gene mutagen in lung tissues of
mice.
ARTICLES
Inhaled benzene increases the frequency and length of lacI deletion mutations in lung tissues of mice
Cell and Molecular Biology Department and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118-5698, USA.
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