Carcinogenesis, Vol 19, 1943-1947, Copyright © 1998 by Oxford University Press
RC Millikan, GS Pittman, CK Tse, E Duell, B Newman, D Savitz, PG Moorman, RJ Boissy and DA Bell
Recent studies suggest that a polymorphism in catechol-O- methyltransferase
(COMT) is associated with increased risk of breast cancer. Methylation by
COMT is the principal pathway for inactivation of catechol estrogens, which
are hypothesized to participate in estrogen-induced carcinogenesis. We
examined the association of COMT genotype and breast cancer risk in a
population-based, case-control study of invasive breast cancer in North
Carolina. The study population consisted of 654 cases and 642 controls,
with approximately equal numbers of African-American and white women and
women under the age of 50 and aged 50 or over. Contrary to previous
reports, we did not observe an association between one or more copies of
the low activity COMT allele (COMT-L) and breast cancer risk. Multivariate
relative risks (RRs) were 0.8 (95% confidence interval: 0.6-1.1) for
COMT-HL and 0.8 (0.6-1.1) for COMT-LL, compared with the COMT-HH genotype.
RRs for COMT did not differ among African-American and white women and we
did not observe strong modification of RR estimates by menopausal status,
body mass index, physical activity or other covariates. Our results suggest
that COMT genotype is not related to breast cancer risk.
ARTICLES
Catechol-O-methyltransferase and breast cancer risk
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599-7400, USA. bob_millikan@unc.edu
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|
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|
|
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|
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|
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|
|
|
|
 |
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|
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|
|
|
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|
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|
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|
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