Carcinogenesis, Vol 19, 1963-1968, Copyright © 1998 by Oxford University Press
G Pan, T Hanaoka, Y Yamano, K Hara, M Ichiba, Y Wang, J Zhang, Y Feng, Z Shujuan, D Guan, G Gao, N Liu and K Takahashi
We conducted a cross-sectional molecular epidemiological study of coke oven
workers exposed to the established carcinogen polycyclic aromatic
hydrocarbons (PAHs) to evaluate the relationships between both traditional
'exposure markers' and a series of biomarkers, including urinary
1-hydroxypyrene as a marker of internal dose, leukocyte aromatic DNA
adducts as markers of biologically effective dose, serum p53 protein as a
response marker and genetic polymorphisms of cytochrome P4501A1 and
glutathione S-transferase MI as susceptibility markers. Twenty-five male
subjects each were randomly selected from the top, middle and bottom work
areas of the oven, and the control plant. They were matched for age and
smoking status. The mean levels of PAH exposure, monitored by stationary
and personal samplers, and of worker urinary 1-hydroxypyrene differed
significantly between the top, middle and bottom of the oven and control
work areas. The highest stationary and personal PAH concentrations and
1-hydroxypyrene levels were demonstrated at the top work area. Good
correlations were found between the stationary PAH levels, personal PAH
levels and urinary 1- hydroxypyrene levels. No positive correlations were
demonstrated between aromatic DNA adduct levels and current or cumulative
PAH exposure dose. In the presence of genetic polymorphisms of cytochrome
P4501A1, a positive correlation was demonstrated between aromatic DNA
adducts and urinary 1-hydroxypyrene levels. There was also a significant
correlation between serum p53 protein levels and the cumulated
benzo[a]pyrene exposure dose. Although these biomarkers have certain
limitations, they are applicable to cancer epidemiology, and may contribute
to our understanding of the mechanisms of carcinogenesis.
ARTICLES
A study of multiple biomarkers in coke oven workers--a cross-sectional study in China
Liaoning Public Health and Anti-epidemic Station Heping District, Shenyang, People's Republic of China.
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