Carcinogenesis, Vol 19, 2201-2204, Copyright © 1998 by Oxford University Press
M Barthelman, WB Bair 3rd, KK Stickland, W Chen, BN Timmermann, S Valcic, Z Dong and GT Bowden
Green tea polyphenols have been shown to inhibit cancer in a variety of
tumor models, including ultraviolet B (UVB)-induced non-melanoma skin
cancer. In green tea extracts, the major dry mass constituent is the family
of catechins, of which (-)-epigallocatechin-(3)-gallate (EGCG) is
considered to be important for the chemopreventive activity. EGCG has been
shown to have antioxidant properties, but there has been little progress
toward identifying the specific targets and mechanisms of its action. Using
cultured human keratinocytes, we show that UVB- induced AP-1 activity is
inhibited by EGCG in a dose range of 5.45 nM to 54.5 microM. EGCG is
effective at inhibiting AP-1 activity when applied before, after or both
before and after UVB irradiation. EGCG also inhibits AP-1 activity in the
epidermis of a transgenic mouse model. This work begins to define a
mechanism by which EGCG could be acting to inhibit UVB-induced tumor
formation.
ARTICLES
(-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity
Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson 85724, USA.
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