Carcinogenesis, Vol 19, 501-507, Copyright © 1998 by Oxford University Press
JM Landau, ZY Wang, GY Yang, W Ding and CS Yang
We investigated the effects of black tea (BT) and green tea (GT) infusion
on the spontaneous formation of lung tumors and rhabdomyosarcomas in A/J
mice. Female A/J mice, 6 weeks of age, were allocated into five groups (50
per group) and were given the following as the sole source of drinking
fluid: (i) deionized water (control group), (ii) 0.5% BT, (iii) 1% BT, (iv)
2% BT and (v) 1% GT. After 60 weeks, the mice were killed by decapitation.
Lung tumor incidence, multiplicity and volume were significantly lower in
the 2% BT group as compared with the controls (27 versus 52%, 0.33 versus
0.72 tumors/mouse and 4.27 versus 38.3 mm3, respectively). The 1% GT group
had significantly lower lung tumor multiplicity (0.41/mouse), while the 1%
BT group had significantly decreased tumor volume (7.17 mm3).
Rhabdomyosarcomas were found in 34% of the mice in the control group, and
both the 1 and 2% BT groups had significantly lower incidences at 13 and
14%, respectively. The mice in the 2% BT group weighed 16% less than those
in the control group, although they consumed more food than the control
group. The other tea-consuming groups also weighed less than the control
group (7.8-11%) while consuming more food and fluid. In a separate
experiment, similar carcinogenesis inhibition was also observed in female
A/J mice that were given 0.6% and then 0.3% instant black tea for 52 weeks.
These results demonstrate the inhibitory activity of BT against the
spontaneous formation of lung tumors and rhabdomyosarcomas in mice.
ARTICLES
Inhibition of spontaneous formation of lung tumors and rhabdomyosarcomas in A/J mice by black and green tea
Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
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