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Carcinogenesis, Vol 19, 519-523, Copyright © 1998 by Oxford University Press

ARTICLES

Adaptive response of human melanoma cells to methylglyoxal injury

F Amicarelli, T Bucciarelli, A Poma, P Aimola, C Di Ilio, AM Ragnelli and M Miranda
Department of Basic and Applied Biology, University of L'Aquila, Italy.

The effects of methylglyoxal on the growth of a line of human melanoma cells are investigated. Methylglyoxal inhibits cell growth in a dose- dependent manner and causes an increase in glyceraldehyde 3-phosphate dehydrogenase, and glyoxalase 1 and glyoxalase 2 specific activities. The cellular response to increasing concentrations of methylglyoxal in the culture medium is also studied by measuring L-lactate production, reduced-oxidized glutathione levels and apoptotic cell death. Methylglyoxal seems to promote a change of cell population phenotypic repertoire toward a more monomorphic phenotype. In conclusion, methylglyoxal seems to induce an enzymatic cellular response that lowers methylglyoxal levels and selects the most resistant cells.
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