Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (57)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Piperakis, S. M.
Right arrow Articles by Tassiou, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piperakis, S. M.
Right arrow Articles by Tassiou, A. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol 19, 695-698, Copyright © 1998 by Oxford University Press

ARTICLES

Effects of smoking and aging on oxidative DNA damage of human lymphocytes

SM Piperakis, EE Visvardis, M Sagnou and AM Tassiou
Department of Biology, National Center for Scientific Research Demokritos, Aghia Paraskevi, Athens, Greece. piper@cyclades.nrcps.ariadne-t.gr

The effects of H2O2-induced oxidative DNA damage in 80 healthy individuals with relation to age (20-25 and 55-60 years old) and smoking has been investigated with the comet assay technique. Both factors have shown a significant effect upon basal DNA damage with smoking appearing to have the most impact. A differentiation of the four groups response to induced oxidative damage was also observed. A distinctly separate behavior of the younger non-smokers group, when compared with the rest of the categories, was found. This is attributed to the lower degree of initial basal damage that occurs in their lymphocytes.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
X. Zhao, G. Aldini, E. J Johnson, H. Rasmussen, K. Kraemer, H. Woolf, N. Musaeus, N. I Krinsky, R. M Russell, and K.-J. Yeum
Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women
Am. J. Clinical Nutrition, January 1, 2006; 83(1): 163 - 169.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
H. Hoffmann, J. Hogel, and G. Speit
The effect of smoking on DNA effects in the comet assay: a meta-analysis
Mutagenesis, November 1, 2005; 20(6): 455 - 466.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. Briviba, S. E. Kulling, J. Moseneder, B. Watzl, G. Rechkemmer, and A. Bub
Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers
Carcinogenesis, December 1, 2004; 25(12): 2373 - 2378.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
Y. Jang, J. Y. Kim, O. Y. Kim, J. E. Lee, H. Cho, J. M Ordovas, and J. H. Lee
The -1131T->C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men
Am. J. Clinical Nutrition, October 1, 2004; 80(4): 832 - 840.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. J. Marlin, L. Johnson, D. A. Kingston, N. C. Smith, C. M. Deaton, S. Mann, P. Heaton, F. Van Vugt, K. Saunders, J. Kydd, et al.
Application of the Comet Assay for Investigation of Oxidative DNA Damage in Equine Peripheral Blood Mononuclear Cells
J. Nutr., August 1, 2004; 134(8): 2133S - 2140S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. F. Ellahuene, L. P. Perez-Alzola, M. Farfan-Urzua, P. Gonzalez-Hormazabal, M. Garay, M. I. Olmedo, and J. A. Last
Preliminary Evaluation of DNA Damage Related with the Smoking Habit Measured by the Comet Assay in Whole Blood Cells
Cancer Epidemiol. Biomarkers Prev., July 1, 2004; 13(7): 1223 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
Y. Jang, O. Y. Kim, H. J. Ryu, J. Y. Kim, S. H. Song, J. M. Ordovas, and J. H. Lee
Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men
J. Lipid Res., December 1, 2003; 44(12): 2356 - 2364.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
S. I. Tsilimigaki, N. Messini-Nikolaki, M. Kanariou, and S. M. Piperakis
A study on the effects of seasonal solar radiation on exposed populations
Mutagenesis, March 1, 2003; 18(2): 139 - 143.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
L. Giovannelli, C. Saieva, G. Masala, G. Testa, S. Salvini, V. Pitozzi, E. Riboli, P. Dolara, and D. Palli
Nutritional and lifestyle determinants of DNA oxidative damage: a study in a Mediterranean population
Carcinogenesis, September 1, 2002; 23(9): 1483 - 1489.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A.B. Nia, F.J. Van Schooten, P.A.E.L. Schilderman, T.M.C.M. De Kok, G.R. Haenen, M.H.M. Van Herwijnen, E. Van Agen, D. Pachen, and J.C.S. Kleinjans
A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms
Carcinogenesis, March 1, 2001; 22(3): 395 - 401.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. Møller, L. E. Knudsen, S. Loft, and H. Wallin
The Comet Assay as a Rapid Test in Biomonitoring Occupational Exposure to DNA-damaging Agents and Effect of Confounding Factors
Cancer Epidemiol. Biomarkers Prev., October 1, 2000; 9(10): 1005 - 1015.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
S. Zienolddiny, D. Ryberg, and A. Haugen
Induction of microsatellite mutations by oxidative agents in human lung cancer cell lines
Carcinogenesis, August 1, 2000; 21(8): 1521 - 1526.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.