Carcinogenesis, Vol 19, 1039-1043, Copyright © 1998 by Oxford University Press
K Singletary, C MacDonald, M Iovinelli, C Fisher and M Wallig
Curcumin is a beta-diketone constituent of the spice turmeric that
possesses anticarcinogenic properties in several animal models. The present
studies were conducted in order to identify beta-diketones
structurally-related to curcumin that would be effective dietary blocking
agents toward the initiation stage of 7,12- dimethylbenz[a]anthracene
(DMBA)-induced rat mammary carcinogenesis. Of the beta-diketone compounds
initially screened for their capacity to induce quinone-reductase (QR)
activity in wild-type Hepa1c1c7 cells and a mutant subclone, curcumin
(diferuloylmethane) and dibenzoylmethane were most effective. However, when
added to semipurified diets fed to female rats, dibenzoylmethane (1%), but
not curcumin (1%), was effective in inhibiting in vivo mammary DMBA-DNA
adduct formation. This inhibitory effect on mammary adduct formation was
associated with a significant increase in liver activities of glutathione
S-transferase, QR and 7-ethoxyresorufin-O-deethylase activities. Female
rats provided diets supplemented with dibenzoylmethane at 0.1, 0.5 and 1.0%
for 14 days prior to dosing with DMBA exhibited a significant decrease in
mammary tumor development, compared with controls. However, tumor
development for animals fed diets containing 1.0% curcumin was not
different from that of controls. Therefore, dibenzoylmethane, and possibly
other structurally-related beta-diketones, warrant examination as breast
cancer chemopreventative blocking agents.
ARTICLES
Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12- dimethylbenz[a]anthracene
Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana 61801, USA.
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