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Carcinogenesis, Vol 19, 1149-1151, Copyright © 1998 by Oxford University Press

ARTICLES

Urokinase receptor genotypes in colorectal cancer

M Kohonen-Corish, J Young, G Chenevix-Trench and WF Doe
Division of Molecular Medicine, John Curtin School of Medical Research, Australian National University, Canberra, ACT. Maija.Corish@anu.edu.au

A previous study has reported a high frequency of rare alleles of the urokinase-type plasminogen activator receptor (uPAR) in a set of 15 colorectal cancer (CRC) cell lines. Our study investigated uPAR gene variation in 92 CRC patients and in tumour DNA from a subset of 69 patients using the PLAUR-IVS3 marker located in an intron of this gene. The overall distribution of the marker alleles in the patients did not differ significantly from a set of 105 controls. A pairwise analysis of individual allele frequencies showed, however, that the common allele 147 was significantly decreased (P = 0.027) and allele 149 was significantly increased (P = 0.033) in the patients. These results may indicate an effect of uPAR gene variation in CRC carcinogenesis and encourages further examination of this marker in an independent series of patients.
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