Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Daher, A.
Right arrow Articles by Oth, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Daher, A.
Right arrow Articles by Oth, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol 19, 1553-1558, Copyright © 1998 by Oxford University Press

ARTICLES

Effect of pre-conceptional external or internal irradiation of N5 male mice and the risk of leukemia in their offspring

A Daher, M Varin, Y Lamontagne and D Oth
Centre de Recherche en Immunologie, Institut Armand-Frappier, Quebec, Canada.

Male mice of the N5 strain were exposed to a unique external X-ray dose of 500 cGy, or to i.p. injections of tritiated water (HTO) over a 30 day period, which resulted in an estimated total internal exposure of 150 cGy. The paternal X-ray irradiation resulted in a marginally significant (P = 0.07) doubling of the leukemia/lymphoma rate in the offspring, over a 1 year observation period. The constitutive gene expression of granulocyte-macrophage colony stimulating factor (GM-CSF) and tumour necrosis factor (TNF) (two cytokines associated with hematopoiesis and immune response) spontaneously diminished between the ages of 6 months and 12 months in the bone marrows and in the spleens of these mice, and paternal X-ray exposure influenced the statistical significance of this diminution. Male exposure to HTO resulted in a statistically significant several-fold increase of leukemia incidence among the young offspring. However this increase tended to diminish as older mice were observed, and was no longer significant at 1 year of age. The overall leukemia incidence in the offspring of the HTO-exposed fathers was significantly dependent on the maturation stage of the sperm-forming cells during the HTO exposure, which suggests an influence of such an exposure.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
A. Daher, G. Laraki, M. Singh, C. E. Melendez-Pena, S. Bannwarth, A. H. F. M. Peters, E. F. Meurs, R. E. Braun, R. C. Patel, and A. Gatignol
TRBP Control of PACT-Induced Phosphorylation of Protein Kinase R Is Reversed by Stress
Mol. Cell. Biol., January 1, 2009; 29(1): 254 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
X. O. Shu, J. D. Potter, M. S. Linet, R. K. Severson, D. Han, J. H. Kersey, J. P. Neglia, M. E. Trigg, and L. L. Robison
Diagnostic X-Rays and Ultrasound Exposure and Risk of Childhood Acute Lymphoblastic Leukemia by Immunophenotype
Cancer Epidemiol. Biomarkers Prev., February 1, 2002; 11(2): 177 - 185.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.