Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (53)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brown, N. M.
Right arrow Articles by Lamartiniere, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, N. M.
Right arrow Articles by Lamartiniere, C. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol 19, 1623-1629, Copyright © 1998 by Oxford University Press

ARTICLES

Prenatal TCDD and predisposition to mammary cancer in the rat

NM Brown, PA Manzolillo, JX Zhang, J Wang and CA Lamartiniere
Department of Pharmacology and Toxicology, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, 35294, USA.

Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated for its potential to predispose to breast cancer. Analysis of mammary gland differentiation and cell proliferation were used as biomarkers. Timed pregnant Sprague-Dawley CD rats were gavaged with 1 microg TCDD/kg on day 15 post-conception. Control animals were treated with the same volume of vehicle (sesame oil) on the same schedule. Mammary gland differentiation studies revealed that prenatal TCDD treatment, as compared with sesame oil treatment, resulted in significantly more terminal end buds and fewer lobules II in 50-day-old offspring, but no significant alterations to mammary gland differentiation in 21-day-old offspring. Terminal end buds are the most susceptible terminal ductal structures and lobules the least susceptible to carcinogenesis. Prenatal TCDD treatment did not alter labeling index in the mammary terminal ductal structures of 21- and 50- day-old rats, but the total proliferative compartment in terminal end buds of 50-day-old rats was larger. Prenatal TCDD treatment resulted in an increased number of chemically induced mammary adenocarcinomas in rats. TCDD delayed time of vaginal opening and caused disruption to the estrous cycle. Alteration to mammary gland differentiation (increased number of terminal end buds) is correlated with increased susceptibility to mammary cancer from prenatal exposure to TCDD.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
E. Diamanti-Kandarakis, J.-P. Bourguignon, L. C. Giudice, R. Hauser, G. S. Prins, A. M. Soto, R. T. Zoeller, and A. C. Gore
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Endocr. Rev., June 1, 2009; 30(4): 293 - 342.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
H. Buteau-Lozano, G. Velasco, M. Cristofari, P. Balaguer, and M. Perrot-Applanat
Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism
J. Endocrinol., February 1, 2008; 196(2): 399 - 412.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
E. L. Hsu, D. Yoon, H. H. Choi, F. Wang, R. T. Taylor, N. Chen, R. Zhang, and O. Hankinson
A Proposed Mechanism for the Protective Effect of Dioxin against Breast Cancer
Toxicol. Sci., August 1, 2007; 98(2): 436 - 444.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Z. Shi, K. E. Valdez, A. Y. Ting, A. Franczak, S. L. Gum, and B. K. Petroff
Ovarian Endocrine Disruption Underlies Premature Reproductive Senescence Following Environmentally Relevant Chronic Exposure to the Aryl Hydrocarbon Receptor Agonist 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Biol Reprod, February 1, 2007; 76(2): 198 - 202.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. E. Fenton
Endocrine-Disrupting Compounds and Mammary Gland Development: Early Exposure and Later Life Consequences
Endocrinology, June 1, 2006; 147(6): s18 - s24.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
D. R. Boverhof, J. C. Kwekel, D. G. Humes, L. D. Burgoon, and T. R. Zacharewski
Dioxin Induces an Estrogen-Like, Estrogen Receptor-Dependent Gene Expression Response in the Murine Uterus
Mol. Pharmacol., May 1, 2006; 69(5): 1599 - 1606.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Baba, J. Mimura, N. Nakamura, N. Harada, M. Yamamoto, K.-i. Morohashi, and Y. Fujii-Kuriyama
Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction
Mol. Cell. Biol., November 15, 2005; 25(22): 10040 - 10051.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
H Watanabe, A Suzuki, M Goto, S Ohsako, C Tohyama, H Handa, and T Iguchi
Comparative uterine gene expression analysis after dioxin and estradiol administration
J. Mol. Endocrinol., December 1, 2004; 33(3): 763 - 771.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. C. Larsen, P. B. Brake, R. S. Pollenz, and C. R. Jefcoate
Linked Expression of Ah Receptor, ARNT, CYP1A1, and CYP1B1 in Rat Mammary Epithelia, in Vitro, Is Each Substantially Elevated by Specific Extracellular Matrix Interactions that Precede Branching Morphogenesis
Toxicol. Sci., November 1, 2004; 82(1): 46 - 61.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
B. A. Vorderstrasse, S. E. Fenton, A. A. Bohn, J. A. Cundiff, and B. P. Lawrence
A Novel Effect of Dioxin: Exposure during Pregnancy Severely Impairs Mammary Gland Differentiation
Toxicol. Sci., April 1, 2004; 78(2): 248 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
W. G. Foster, E. V. Younglai, O. Boutross-Tadross, C. L. Hughes, and M. G. Wade
Mammary Gland Morphology in Sprague-Dawley Rats following Treatment with an Organochlorine Mixture in Utero and Neonatal Genistein
Toxicol. Sci., January 1, 2004; 77(1): 91 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. E. Fenton, J. T. Hamm, L. S. Birnbaum, and G. L. Youngblood
Persistent Abnormalities in the Rat Mammary Gland following Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
Toxicol. Sci., May 1, 2002; 67(1): 63 - 74.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
B. C. Lewis, S. Hudgins, A. Lewis, K. Schorr, R. Sommer, R. E. Peterson, J. A. Flaws, and P. A. Furth
In Utero and Lactational Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin Impairs Mammary Gland Differentiation but Does Not Block the Response to Exogenous Estrogen in the Postpubertal Female Rat
Toxicol. Sci., July 1, 2001; 62(1): 46 - 53.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. W. Davis II, F. T. Lauer, A. D. Burdick, L. G. Hudson, and S. W. Burchiel
Prevention of Apoptosis by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A Cell Line: Correlation with Increased Transforming GrowthFactor {{alpha}} Production
Cancer Res., April 1, 2001; 61(8): 3314 - 3320.
[Abstract] [Full Text]

Home page
 CMAJHome page
G. M. Solomon and T. Schettler
Environment and health: 6. Endocrine disruption and potential human health implications
Can. Med. Assoc. J., November 1, 2000; 163(11): 1471 - 1476.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.