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Carcinogenesis, Vol. 20, No. 10, 1957-1961, October 1999
© 1999 Oxford University Press

Molecular Epidemiology and Cancer Prevention

Induction of AP-1 activity by perillyl alcohol in breast cancer cells

Yoshiko Satomi, Shigeki Miyamoto1 and Michael N. Gould2

McArdle Laboratory for Cancer Research and
1 Department of Pharmacology, University of Wisconsin–Madison, Madison, WI 53792, USA

Monoterpenes display chemopreventive and therapeutic activity in rat mammary tumor models. Monoterpenes can also inhibit cell growth and induce apoptosis of cultured cells. In this study, the monoterpene perillyl alcohol (POH) was found to induce transient expression of the c-jun and c-fos genes transcriptionally. POH also transiently induced phosphorylation of c-Jun protein. These events were associated with transcriptional activation of an AP-1-dependent reporter gene. These results suggest that POH might affect c-Jun activity via the Jun N-terminal kinase/stress-activated protein kinase pathway and modulate expression of AP-1 target genes.

Abbreviations: ACD, actinomycin D; AP-1, activator protein 1; CHX, cycloheximide; JNK, Jun N-terminal kinase; M6P/IGF2R, mannose 6-phosphate/insulin-like growth factor 2 receptor; PBS, phosphate-buffered saline; POH, perillyl alcohol; TGFß1, transforming growth factor ß1; TNF{alpha}, tumor necrosis factor {alpha}; TPA, 12-O-tetradecanoylphorbol-13-acetate.

2 To whom correspondence should be addressedEmail: gould{at}oncology.wisc.edu


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