Carcinogenesis, Vol. 20, No. 3, 499-502,
March 1999
© 1999 Oxford University Press
Short Communications |
Frameshift mutations in TGFßRII, IGFIIR, BAX, hMSH3 and hMSH6 are absent in lung cancers
1 Department of Internal Medicine and Pulmonary Medicine,
2 Pathology and Clinical Laboratories and
3 Thoracic Surgery, Aichi Cancer Center Hospital and
4 Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, Kanokoden, Chikusa-ku, Nagoya 464-8681 and
5 Department of Internal Medicine II, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan
A genome-wide instability at simple repeat sequences characterizes gastrointestinal and endometrial cancers of the microsatellite mutator phenotype (MMP). The genes encoding transforming growth factor-ß receptor type II (TGFßRII), insulin-like growth factor II receptor (IGFIIR), Bcl-2 associated X protein (BAX), hMSH3 and hMSH6 have simple repeat sequences in their coding regions. Consequently, mutations in the single repeat sequences in these genes provide one major route for carcinogenesis in these cancers. We examined 43 non-small cell lung carcinomas and 16 small cell carcinomas for frameshift mutations in simple repeat sequences of TGFßRII, IGFIIR, BAX, hMSH3 and hMSH6. In addition, MMP was assessed using a primer set for BAT-26. None of 59 lung cancers exhibited frameshift mutations or MMP. It is concluded that somatic frameshift mutations in these genes and MMP do not constitute important mechanisms in lung carcinogenesis. The possibility of some sort of genetic instability undetectable as a form of MMP cannot be precluded.
Abbreviations: BAX, Bcl-2-associated X protein; HNPCC, hereditary non-polyposis colorectal cancer; IGFIIR, insulin-like growth factor II receptor gene; MMP, microsatellite mutator phenotype; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancers; TGFßRII, transforming growth factor-ß receptor type II gene.
6 To whom correspondence should be addressed Email: mitsudom{at}leo.bekkoame.or.jp
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