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Carcinogenesis, Vol. 20, No. 4, 685-689, April 1999
© 1999 Oxford University Press

Lack of effect of a 60 Hz magnetic field on biomarkers of tumor promotion in the skin of SENCAR mice

John DiGiovanni4, Dennis A. Johnston, Tim Rupp, Lyle B. Sasser1, Larry E. Anderson1, James E. Morris1, Douglas L. Miller1, Robert Kavet2 and Earl F. Walborg, Jr3

University of Texas M.D.Anderson Cancer Center, Science Park–Research Division, PO Box 389, Smithville, TX 78957,
1 Battelle, Pacific Northwest Laboratories, PO Box 999, Richland, WA 99352,
2 EPRI, 3412 Hillview Avenue, Palo Alto, CA 94304 and
3 Dermigen Inc., PO Box 727, Smithville, TX 78957, USA

It has been proposed that extremely low frequency magnetic fields may enhance tumorigenesis through a co-promotional mechanism. This hypothesis has been further tested using the two-stage model of mouse skin carcinogenesis, i.e. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of skin carcinogenesis in mice initiated by a single subcarcinogenic dose of 7,12-dimethylbenz-[a]anthracene. Experimentation utilized three different doses of TPA within its dose–response range (0.85, 1.70 or 3.40 nmol) and examined the following early biomarkers of tumor promotion after 1, 2 and 5 weeks of promotion: increases in epidermal thickness and the labeling index of epidermal cells, induction of epidermal ornithine decarboxylase activity and down-regulation of epidermal protein kinase C activity. Mice exposed to a 60 Hz magnetic field having a flux density of 2 mT for 6 h/day for 5 days/week were compared with mice exposed to an ambient magnetic field. Within the sensitivity limits of the biomarker methodology and the exposure parameters employed, no consistent, statistically significant effects indicative of promotion or co-promotion by the magnetic field were demonstrated.

Abbreviations: BrdUrd, 2-bromodeoxyuridine; DMBA, dimethylbenz[a]anthracene; ELF, extremely low frequency; ODC, ornithine decarboxylase; PKC, protein kinase C; TPA, 12-O-tetradecanoylphorbol-13-acetate.

4 To whom correspondence should be addressed Email: sa83107{at}odin.mdacc.tmc.edu


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