Carcinogenesis, Vol. 20, No. 7, 1375-1378,
July 1999
© 1999 Oxford University Press
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Chemoprevention of tobacco smoke-induced lung tumors in A/J strain mice with dietary myo-inositol and dexamethasone
Institute of Toxicology and Environmental Health and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Male A/J strain mice were fed AIN-76A diet supplemented with myo-inositol/dexamethasone (10 g and 0.5 mg/kg diet) or acetylsalicylic acid (300 mg/kg) and exposed for 5 months to a mixture of sidestream and mainstream cigarette smoke at a concentration of 132 mg total suspended particulates/m3. After tobacco smoke exposure, they were allowed to recover for another 4 months in filtered air. In the animals fed AIN-75A diet alone or acetylsalicylic acid, the average number of tumors/lung was 2.1, whereas in the animals given the myo-inositol/dexamethasone diet, the average lung tumor multiplicity was 1.0 (P < 0.05). In animals exposed to filtered air, lung tumor multiplicities were 0.6 for animals fed AIN-76A or myo-inositol/dexamethasone and 1.2 for animals fed acetylsalicylic acid. It was concluded that the combination of myo-inositol and dexamethasone constitutes an effective chemopreventive regimen against tobacco smoke-induced lung tumorigenesis.
Abbreviations: B[a]P, benzo[a]pyrene; NAC, N-acetylcysteine; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; PEITC, phenethylisothiocyanate; TSP, total suspended particulates.
1 To whom correspondence should be adressed at: ITEH, University of California, 1 Shields Avenue, Davis, CA 95616, USA Email: hrwitschi{at}ucdavis.edu
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