Carcinogenesis, Vol. 20, No. 8, 1607-1614,
August 1999
© 1999 Oxford University Press
Carcinogenesis |
Catalytic properties of polymorphic human cytochrome P450 1B1 variants
Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-chome, Higashinari-ku, Osaka 537-0025 and
1 Saitama Cancer Center Research Institute, Kitaadachi-gun, Saitama 362-0806, Japan,
2 Division of Toxicological Sciences, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD, 21205 and
3 Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA and
4 Department of Physiology and Pharmacology, The University of Queensland, St Lucia, Queensland 4072, Australia
Four polymorphic human cytochrome P450 (CYP) 1B1 allelic variants, namely Arg48,Ala119,Leu432,Asn453, Arg48,Ser119,Leu432,Asn453, Arg48,Ala119,Val432,Asn-453 and Arg48,Ser119,Val432,Asn453, were expressed in Escherichia coli together with human NADPH-P450 reductase and the recombinant proteins (in bacterial membranes) were used to assess whether CYP1B1 polymorphisms affect catalytic activities towards a variety of P450 substrates, including diverse procarcinogens and steroid hormones. Activities for activation of 19 procarcinogens to DNA-damaging products by these four CYP1B1 variants in a Salmonella typhimurium NM2009 umu response system were found to be essentially similar, except that a Arg48, Ser119,Leu432,Asn453 variant was slightly more active (1.2- to 1.5-fold) than the other three CYP1B1 enzymes in catalyzing activation of (+)- and (–)-benzo[a]pyrene-7,8-diols, 7,12-dimethylbenz[a]anthracene-3,4-diol, benzo[g]chrysene-11,12-diol, benzo[b]fluoranthene-9,10-diol,2-amino-3,5-dimethylimidazo[4,5-f]quinoline, 2-amino-3-methylimidazo[4,5-f]quinoline and 2-aminofluorene. Kinetic analysis of 17ß-estradiol hydroxylation showed that Vmax values for 4-hydroxylation ranged between 0.9 and 1.5 nmol/min/nmol P450 for 4-hydroxylation and 0.3 and 0.6 nmol/min/nmol P450 for 2-hydroxylation in these CYP1B1 variants, with Km values ranging from 1 to 9 µM. Interestingly, the ratio of product formation of 4-hydroxyestradiol to 2-hydroxyestradiol was higher for the Val432 variants of CYP1B1 variants than the Leu432 variants of the enzyme. The same trend was noted in the ratio of estrone 4-hydroxylation to estrone 2-hydroxylation catalyzed by CYP1B1 variants. Mutation in the CYP1B1 genes also affected the Km and Vmax values in the 6ß-hydroxylation of testosterone and 6ß- and 16
-hydroxylation of progesterone. These results indicate that the polymorphisms in the human CYP1B1 gene cause some alterations in catalytic function towards procarcinogens and steroid hormones and thus may make some contribution to susceptibilities of individuals towards mammary and lung cancers in humans.
Abbreviations: B[g]C, benzo[g]chrysene; B[b]F, benzo[b]fluoranthene; B[a]P, benzo[a]pyrene; B[c]P, benzo[c]phenanthrene; CYP, cytochrome P450; DB[a,l]P, dibenzo[a,l]pyrene; DMBA, 7,12-dimethylbenz[a]anthracene; hNPR, human NADPH-P450 reductase; IQ, 2-amino-3-methylimidazo [4,5-f]quinoline; MeIQ, 2-amino-3,5-dimethylimidazo[4,5-f]quinoline; MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; Trp-P-1, 3-amino-1,4-dimethyl5H-pyrido[4,3-b]indole; diol, used in the text to designate the prefix `dihydroxydihydro' for individual polycyclic hydrocarbons.
5 To whom correspondence should be addressed Email: shimada{at}iph.pref.osaka.jp (T.S.); gillam{at}plpk.uq.edu.au (E.M.J.G.)
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. N. Timofeeva, S. Kropp, W. Sauter, L. Beckmann, A. Rosenberger, T. Illig, B. Jager, K. Mittelstrass, H. Dienemann, The LUCY-Consortium, et al. CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences Carcinogenesis, July 1, 2009; 30(7): 1161 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cotterchio, B. A. Boucher, M. Manno, S. Gallinger, A. B. Okey, and P. A. Harper Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-Metabolizing Enzymes, and Colorectal Cancer Risk Cancer Epidemiol. Biomarkers Prev., November 1, 2008; 17(11): 3098 - 3107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Beuten, J. A.L. Gelfond, J. J. Byrne, I. Balic, A. C. Crandall, T. L. Johnson-Pais, I. M. Thompson, D. K. Price, and R. J. Leach CYP1B1 variants are associated with prostate cancer in non-Hispanic and Hispanic Caucasians Carcinogenesis, September 1, 2008; 29(9): 1751 - 1757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Diergaarde, J. D. Potter, E. R. Jupe, S. Manjeshwar, C. D. Shimasaki, T. W. Pugh, D. C. DeFreese, B. A. Gramling, I. Evans, and E. White Polymorphisms in Genes Involved in Sex Hormone Metabolism, Estrogen Plus Progestin Hormone Therapy Use, and Risk of Postmenopausal Breast Cancer Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1751 - 1759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Castro, W. M. Baird, C. B. Pereira, J. Giovanini, C. V. Lohr, K. A. Fischer, Z. Yu, F. J. Gonzalez, S. K. Krueger, and D. E. Williams Fetal Mouse Cyp1b1 and Transplacental Carcinogenesis from Maternal Exposure to Dibenzo(a,l)pyrene Cancer Prevention Research, July 1, 2008; 1(2): 128 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Sissung, R. Danesi, D. K. Price, S. M. Steinberg, R. de Wit, M. Zahid, N. Gaikwad, E. Cavalieri, W. L. Dahut, D. L. Sackett, et al. Association of the CYP1B1*3 allele with survival in patients with prostate cancer receiving docetaxel Mol. Cancer Ther., January 1, 2008; 7(1): 19 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Vineis, F Veglia, S Garte, C Malaveille, G Matullo, A Dunning, M Peluso, L Airoldi, K Overvad, O Raaschou-Nielsen, et al. Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers Ann. Onc., July 1, 2007; 18(7): 1230 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Nock, D. Tang, A. Rundle, C. Neslund-Dudas, A. T. Savera, C. H. Bock, K. G. Monaghan, A. Koprowski, N. Mitrache, J. J. Yang, et al. Associations between Smoking, Polymorphisms in Polycyclic Aromatic Hydrocarbon (PAH) Metabolism and Conjugation Genes and PAH-DNA Adducts in Prostate Tumors Differ by Race Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1236 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Rebbeck, A. B. Troxel, A. H. Walker, S. Panossian, S. Gallagher, E. G. Shatalova, R. Blanchard, S. Norman, G. Bunin, A. DeMichele, et al. Pairwise Combinations of Estrogen Metabolism Genotypes in Postmenopausal Breast Cancer Etiology Cancer Epidemiol. Biomarkers Prev., March 1, 2007; 16(3): 444 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Paracchini, S. Raimondi, I. T. Gram, D. Kang, N. A. Kocabas, V. N. Kristensen, D. Li, F. F. Parl, T. Rylander-Rudqvist, P. Soucek, et al. Meta- and Pooled Analyses of the Cytochrome P-450 1B1 Val432Leu Polymorphism and Breast Cancer: A HuGE-GSEC Review Am. J. Epidemiol., January 15, 2007; 165(2): 115 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cotterchio, B. A. Boucher, M. Manno, S. Gallinger, A. Okey, and P. Harper Dietary Phytoestrogen Intake Is Associated with Reduced Colorectal Cancer Risk J. Nutr., December 1, 2006; 136(12): 3046 - 3053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Hecht, S. G. Carmella, A. Yoder, M. Chen, Z.-z. Li, C. Le, R. Dayton, J. Jensen, and D. K. Hatsukami Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1805 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, B. E. Scheffler, and K. L. Willett CYP1C1 Messenger RNA Expression is Inducible by Benzo[a]pyrene in Fundulus heteroclitus Embryos and Adults Toxicol. Sci., October 1, 2006; 93(2): 331 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Rebbeck, A. B. Troxel, Y. Wang, A. H. Walker, S. Panossian, S. Gallagher, E. G. Shatalova, R. Blanchard, G. Bunin, A. DeMichele, et al. Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk. J Natl Cancer Inst, September 20, 2006; 98(18): 1311 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. De Roos, L. S. Gold, S. Wang, P. Hartge, J. R. Cerhan, W. Cozen, M. Yeager, S. Chanock, N. Rothman, and R. K. Severson Metabolic Gene Variants and Risk of Non-Hodgkin's Lymphoma. Cancer Epidemiol. Biomarkers Prev., September 1, 2006; 15(9): 1647 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Nock, M. S. Cicek, L. Li, X. Liu, B. A. Rybicki, A. Moreira, S. J. Plummer, G. Casey, and J. S. Witte Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk Carcinogenesis, September 1, 2006; 27(9): 1842 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Prince, C. T. Campbell, T. A. Robertson, A. J. Wells, and H. E. Kleiner Naturally occurring coumarins inhibit 7,12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland Carcinogenesis, June 1, 2006; 27(6): 1204 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Nock, X. Liu, M. S. Cicek, L. Li, F. Macarie, B. A. Rybicki, S. J. Plummer, G. T. MacLennan, G. Casey, and J. S. Witte Polymorphisms in polycyclic aromatic hydrocarbon metabolism and conjugation genes, interactions with smoking and prostate cancer risk. Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 756 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. De Roos, N. Rothman, M. Brown, D. A. Bell, G. S. Pittman, W. R. Shapiro, R. G. Selker, H. A. Fine, P. M. Black, and P. D. Inskip Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Neuro-oncol, April 1, 2006; 8(2): 145 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Cribb, M. J. Knight, D. Dryer, J. Guernsey, K. Hender, M. Tesch, and T. M. Saleh Role of polymorphic human cytochrome p450 enzymes in estrone oxidation. Cancer Epidemiol. Biomarkers Prev., March 1, 2006; 15(3): 551 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Sissung, D. K. Price, A. Sparreboom, and W. D. Figg Pharmacogenetics and Regulation of Human Cytochrome P450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic Intervention Mol. Cancer Res., March 1, 2006; 4(3): 135 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Chun, S.-K. Lee, and M. Y. Kim MODULATION OF HUMAN CYTOCHROME P450 1B1 EXPRESSION BY 2,4,3',5'-TETRAMETHOXYSTILBENE Drug Metab. Dispos., December 1, 2005; 33(12): 1771 - 1776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Sellers, J. M. Schildkraut, V. S. Pankratz, R. A. Vierkant, Z. S. Fredericksen, J. E. Olson, J. Cunningham, W. Taylor, M. Liebow, C. McPherson, et al. Estrogen Bioactivation, Genetic Polymorphisms, and Ovarian Cancer Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2536 - 2543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Starr, C. Chen, D. R. Doody, L. Hsu, S. Ricks, N. S. Weiss, and S. M. Schwartz Risk of Testicular Germ Cell Cancer in Relation to Variation in Maternal and Offspring Cytochrome P450 Genes Involved in Catechol Estrogen Metabolism Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2183 - 2190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Le Marchand, T. Donlon, L. N. Kolonel, B. E. Henderson, and L. R. Wilkens Estrogen Metabolism-Related Genes and Breast Cancer Risk: The Multiethnic Cohort Study Cancer Epidemiol. Biomarkers Prev., August 1, 2005; 14(8): 1998 - 2003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.A. Hefler, C. Grimm, G. Heinze, C. Schneeberger, M.W. Mueller, A. Muendlein, J.C. Huber, S. Leodolter, and C.B. Tempfer Estrogen-metabolizing gene polymorphisms and age at natural menopause in Caucasian women Hum. Reprod., May 1, 2005; 20(5): 1422 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, Z. Liu, E. M. Sturgis, R. M. Chamberlain, M. R. Spitz, and Q. Wei CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu Polymorphisms Are Not Associated with Risk of Squamous Cell Carcinoma of the Head and Neck Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 1034 - 1036. [Full Text] [PDF]
|
|
|
|
|
|
W. Wen, Q. Cai, X.-O. Shu, J.-R. Cheng, F. Parl, L. Pierce, Y.-T. Gao, and W. Zheng Cytochrome P450 1B1 and Catechol-O-Methyltransferase Genetic Polymorphisms and Breast Cancer Risk in Chinese Women: Results from the Shanghai Breast Cancer Study and a Meta-analysis Cancer Epidemiol. Biomarkers Prev., February 1, 2005; 14(2): 329 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Doherty, N. S. Weiss, R. J. Freeman, D. A. Dightman, P. J. Thornton, J. R. Houck, L. F. Voigt, M. A. Rossing, S. M. Schwartz, and C. Chen Genetic Factors in Catechol Estrogen Metabolism in Relation to the Risk of Endometrial Cancer Cancer Epidemiol. Biomarkers Prev., February 1, 2005; 14(2): 357 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bandiera, S. Weidlich, V. Harth, P. Broede, Y. Ko, and T. Friedberg Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression Mol. Pharmacol., February 1, 2005; 67(2): 435 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Rylander-Rudqvist, S. Wedren, G. Jonasdottir, S. Ahlberg, E. Weiderpass, I. Persson, and M. Ingelman-Sundberg Cytochrome P450 1B1 Gene Polymorphisms and Postmenopausal Endometrial Cancer Risk Cancer Epidemiol. Biomarkers Prev., September 1, 2004; 13(9): 1515 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. McGrath, S. E. Hankinson, L. Arbeitman, G. A. Colditz, D. J. Hunter, and I. De Vivo Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility Carcinogenesis, April 1, 2004; 25(4): 559 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sasaki, Y. Tanaka, S. T. Okino, M. Nomoto, S. Yonezawa, M. Nakagawa, S. Fujimoto, N. Sakuragi, and R. Dahiya Polymorphisms of the CYP1B1 Gene as Risk Factors for Human Renal Cell Cancer Clin. Cancer Res., March 15, 2004; 10(6): 2015 - 2019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Tworoger, J. Chubak, E. J. Aiello, C. M. Ulrich, C. Atkinson, J. D. Potter, Y. Yasui, P. L. Stapleton, J. W. Lampe, F. M. Farin, et al. Association of CYP17, CYP19, CYP1B1, and COMT Polymorphisms with Serum and Urinary Sex Hormone Concentrations in Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., January 1, 2004; 13(1): 94 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Hachey, S. Dawling, N. Roodi, and F. F. Parl Sequential Action of Phase I and II Enzymes Cytochrome P450 1B1 and Glutathione S-Transferase P1 in Mammary Estrogen Metabolism Cancer Res., December 1, 2003; 63(23): 8492 - 8499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Rylander-Rudqvist, S. Wedren, F. Granath, K. Humphreys, S. Ahlberg, E. Weiderpass, M. Oscarson, M. Ingelman-Sundberg, and I. Persson Cytochrome P450 1B1 gene polymorphisms and postmenopausal breast cancer risk Carcinogenesis, September 1, 2003; 24(9): 1533 - 1539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Lee, M. X. Cai, P. E. Thomas, A. H. Conney, and B. T. Zhu Characterization of the Oxidative Metabolites of 17{beta}-Estradiol and Estrone Formed by 15 Selectively Expressed Human Cytochrome P450 Isoforms Endocrinology, August 1, 2003; 144(8): 3382 - 3398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Mammen, G. S. Pittman, Y. Li, F. Abou-Zahr, B. A. Bejjani, D. A. Bell, P. T. Strickland, and T. R. Sutter Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol Carcinogenesis, July 1, 2003; 24(7): 1247 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Li, F. L. Walcott, P. Chang, W. Zhang, J. Zhu, E. Petrulis, S. E. Singletary, A. A. Sahin, and M. L. Bondy Genetic and Environmental Determinants on Tissue Response to in Vitro Carcinogen Exposure and Risk of Breast Cancer Cancer Res., August 15, 2002; 62(16): 4566 - 4570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Crewe, L. M. Notley, R. M. Wunsch, M. S. Lennard, and E. M. J. Gillam Metabolism of Tamoxifen by Recombinant Human Cytochrome P450 Enzymes: Formation of the 4-Hydroxy, 4'-Hydroxy and N-Desmethyl Metabolites and Isomerization of trans-4-Hydroxytamoxifen Drug Metab. Dispos., August 1, 2002; 30(8): 869 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. R. Stoilov, V. P. Costa, J. P. C. Vasconcellos, M. B. Melo, A. J. Betinjane, J. C. E. Carani, E. V. Oltrogge, and M. Sarfarazi Molecular Genetics of Primary Congenital Glaucoma in Brazil Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 1820 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. De Vivo, S. E. Hankinson, L. Li, G. A. Colditz, and D. J. Hunter Association of CYP1B1 Polymorphisms and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., May 1, 2002; 11(5): 489 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Aklillu, M. Oscarson, M. Hidestrand, B. Leidvik, C. Otter, and M. Ingelman-Sundberg Functional Analysis of Six Different Polymorphic CYP1B1 Enzyme Variants Found in an Ethiopian Population Mol. Pharmacol., March 1, 2002; 61(3): 586 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Chun, S. Kim, D. Kim, S.-K. Lee, and F. P. Guengerich A New Selective and Potent Inhibitor of Human Cytochrome P450 1B1 and Its Application to Antimutagenesis Cancer Res., November 1, 2001; 61(22): 8164 - 8170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimada, Y. Oda, E. M. J. Gillam, F. P. Guengerich, and K. Inoue Metabolic Activation of Polycyclic Aromatic Hydrocarbons and Other Procarcinogens by Cytochromes P450 1A1 and P450 1B1 Allelic Variants and Other Human Cytochromes P450 in Salmonella typhimurium NM2009 Drug Metab. Dispos., September 1, 2001; 29(9): 1176 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dawling, N. Roodi, R. L. Mernaugh, X. Wang, and F. F. Parl Catechol-O-Methyltransferase (COMT)-mediated Metabolism of Catechol Estrogens: Comparison of Wild-Type and Variant COMT Isoforms Cancer Res., September 1, 2001; 61(18): 6716 - 6722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-F. Yueh, N. Nguyen, M. Famourzadeh, C. P. Strassburg, Y. Oda, F.P. Guengerich, and R. H. Tukey The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines Carcinogenesis, June 1, 2001; 22(6): 943 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ko, J. Abel, V. Harth, P. Brode, C. Antony, S. Donat, H.-P. Fischer, M. E. Ortiz-Pallardo, R. Thier, A. Sachinidis, et al. Association of CYP1B1 Codon 432 Mutant Allele in Head and Neck Squamous Cell Cancer Is Reflected by Somatic Mutations of p53 in Tumor Tissue Cancer Res., June 1, 2001; 61(11): 4398 - 4404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Goodman, K. McDuffie, L. N. Kolonel, K. Terada, T. A. Donlon, L. R. Wilkens, C. Guo, and L. Le Marchand Case-Control Study of Ovarian Cancer and Polymorphisms in Genes Involved in Catecholestrogen Formation and Metabolism Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 209 - 216. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Wilson and G. A. Reed Predominant 4-hydroxylation of estradiol by constitutive cytochrome P450s in the female ACI rat liver Carcinogenesis, February 1, 2001; 22(2): 257 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. I. Ghanayem, Hongbing Wang, and S. Sumner Using Cytochrome P-450 Gene Knock-Out Mice to Study Chemical Metabolism, Toxicity, and Carcinogenicity Toxicol Pathol, November 1, 2000; 28(6): 839 - 850. [Abstract] [PDF]
|
|
|
|
|
|
I. H. Hanna, S. Dawling, N. Roodi, F. P. Guengerich, and F. F. Parl Cytochrome P450 1B1 (CYP1B1) Pharmacogenetics: Association of Polymorphisms with Functional Differences in Estrogen Hydroxylation Activity Cancer Res., July 1, 2000; 60(13): 3440 - 3444. [Abstract] [Full Text]
|
|
|
|
|
|
W. Zheng, D.-W. Xie, F. Jin, J.-R. Cheng, Q. Dai, W.-Q. Wen, X.-O. Shu, and Y.-T. Gao Genetic Polymorphism of Cytochrome P450-1B1 and Risk of Breast Cancer Cancer Epidemiol. Biomarkers Prev., February 1, 2000; 9(2): 147 - 150. [Abstract] [Full Text]
|
|