Carcinogenesis, Vol. 20, No. 8, 1625-1628,
August 1999
© 1999 Oxford University Press
Short Communications |
Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice
Department of Urology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603,
1 Department of Public Health and Molecular Toxicology, School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan and
2 Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
We examined the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in transgenic mice deficient in the metallothionein (MT) I and II genes and in control (129/Sv) mice. Both strains of mice were given BBN for 8 weeks with or without Zn treatment. All mice were killed at 12 weeks after the cessation of BBN administration. BBN induced bladder tumors in 75% of MT null mice and in 43% of 129/Sv mice. The average number of bladder tumors per mouse was significantly higher in MT null mice (1.18 ± 0.27) than in 129/Sv mice (0.43 ± 0.20). Zn treatment suppressed the carcinogenicity of BBN in 129/Sv mice but not in MT null mice. Histopathological examination of the tumors revealed that the malignant potential of bladder tumors in 129/Sv mice was greater than that in MT null mice. These results indicate that MT is an important modulator of carcinogenicity of BBN in the bladder of mice.
Abbreviations: BBN, N-butyl-N-(4-hydroxybutyl)nitrosamine; DMBA, 7,12-dimethylbenz[a]anthracene; MT, metallothionein.
3 To whom correspondence should be addressed. Email: imuran{at}mc2.pharm.kitasato-u.ac.jp
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. G. Jeong, C.-K. Youn, H.-J. Cho, S.-H. Kim, M.-H. Kim, H.-B. Kim, I.-Y. Chang, Y.-S. Lee, M.-H. Chung, and H. J. You Metallothionein-III Prevents {gamma}-Ray-induced 8-Oxoguanine Accumulation in Normal and hOGG1-depleted Cells J. Biol. Chem., August 13, 2004; 279(33): 34138 - 34149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Suzuki, N. Nishimura, B. Zhang, Y. Nakatsuru, S. Kobayashi, M. Satoh, and C. Tohyama Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice Carcinogenesis, June 1, 2003; 24(6): 1123 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Greenwald, J. A. Milner, and C. K. Clifford Creating a New Paradigm in Nutrition Research within the National Cancer Institute J. Nutr., December 1, 2000; 130(12): 3103 - 3105. [Abstract] [Full Text] [PDF]
|
|