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Carcinogenesis, Vol. 21, No. 2, 317-319, February 2000
© 2000 Oxford University Press

Short Communications

No change in spontaneous mutation frequency or specificity in dietary restricted mice

Gregory R.Stuart2, Yoshimitsu Oda1, Johan G.de Boer and Barry W.Glickman

Centre for Environmental Health, University of Victoria, PO Box 3020, Victoria, BC, Canada V8W 3N5 and
1 Osaka Prefectural Institute of Public Health, 3-69 Nakamichi 1-Chome, Higashinari-ku, Osaka 537-0025, Japan

It is well known that dietary restricted rodents live longer and are generally healthier than their ad libitum fed counterparts, with fewer tumors. Additionally, while dietary restriction appears to reduce the frequency of chemically induced mutation in laboratory animals, relatively little is known regarding the effect of dietary restriction on spontaneous mutational events. Although spontaneous mutation rates are generally low compared with chemically induced events, spontaneous mutations accumulate in most tissues over the lifetime of the animal and are therefore expected to contribute significantly to spontaneous neoplasia. It is generally presumed that dietary restriction results in less oxidative damage and a lowering of the mutation frequency. Here we report the results of dietary restriction on mutation frequency and specificity in lacI transgenic mice aged 6 and 12 months. Unexpectedly, no changes were observed in either the frequency or specificity of mutation in dietary restricted mice, compared with ad libitum controls. We therefore conclude that dietary restriction appears to have no appreciable effect on spontaneous mutation, at least in chromosomal DNA.

Abbreviations: MF, mutant frequencies; MS, mutational spectra.


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