Carcinogenesis, Vol. 21, No. 3, 371-377,
March 2000
© 2000 Oxford University Press
Carcinogenesis |
Carcinogenesis in mouse and human cells: parallels and paradoxes
UCSF Cancer Center, 2340 Sutter Street, San Francisco, CA 94115, USA and
2 Laboratory of Human Carcinogenesis, Building 37 Room 2C05, 37 Convent Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
It has been known since the last century that genetic changes are important in carcinogenesis [Boveri,T. (1914) Zur Frage der Erstehung Maligner Tumoren. Gustav Fischer, Jena]. Observations of tumor cells growing in tissue culture led to the prediction, even before the true nature of the genetic material was known, that alterations at the chromosomal level were critically involved in the process of neoplastic development. The past 20 years have seen the transition of carcinogenesis studies from the purely observational to the molecular genetic level. Although much more needs to be done, it is nevertheless gratifying to be able to piece together the sequence of events from carcinogen exposure, metabolism of the carcinogen to the activated form, formation of specific carcinogen–DNA adducts, misrepair leading to the fixation of mutations in particular target genes, and the resulting selective outgrowth of neoplastic cells. The nature of many of these steps has been clarified only in the relatively recent past, and only for a small number of specific target genes, but the fact that we can say with confidence that such processes occur and are causal changes in tumorigenesis represents a tremendous advance over the situation pertaining 20 years ago. The purpose of this review is to summarize the advances over this time period in our understanding of some of the genetic alterations that contribute to neoplasia, with particular emphasis on chemical carcinogenesis in rodents and the parallels with transformation of human cells.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. A. Loeb and C. C. Harris Advances in Chemical Carcinogenesis: A Historical Review and Prospective Cancer Res., September 1, 2008; 68(17): 6863 - 6872. [Full Text] [PDF]
|
|
|
|
|
|
K. D. Loomis, S. Zhu, K. Yoon, P. F. Johnson, and R. C. Smart Genetic Ablation of CCAAT/Enhancer Binding Protein {alpha} in Epidermis Reveals Its Role in Suppression of Epithelial Tumorigenesis Cancer Res., July 15, 2007; 67(14): 6768 - 6776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Katzenellenbogen, L. Mizrahi, O. Pappo, N. Klopstock, D. Olam, H. Barash, E. Domany, E. Galun, and D. Goldenberg Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in Mdr2 knockout mice Mol. Cancer Ther., April 1, 2007; 6(4): 1283 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Carver and P. P. Pandolfi Mouse modeling in oncologic preclinical and translational research. Clin. Cancer Res., September 15, 2006; 12(18): 5305 - 5311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Sher, S. Zisman-Rozen, L. Eliahu, J. M. Whitelock, N. Maas-Szabowski, Y. Yamada, D. Breitkreutz, N. E. Fusenig, E. Arikawa-Hirasawa, R. V. Iozzo, et al. Targeting Perlecan in Human Keratinocytes Reveals Novel Roles for Perlecan in Epidermal Formation J. Biol. Chem., February 24, 2006; 281(8): 5178 - 5187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, D. L. Wheeler, W. Alters, L. Chaiswing, A. K. Verma, and T. D. Oberley Early Epidermal Destruction with Subsequent Epidermal Hyperplasia Is a Unique Feature of the Papilloma-Independent Squamous Cell Carcinoma Phenotype in PKC{varepsilon} Overexpressing Transgenic Mice Toxicol Pathol, October 1, 2005; 33(6): 684 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Fraga, M. Herranz, J. Espada, E. Ballestar, M. F. Paz, S. Ropero, E. Erkek, O. Bozdogan, H. Peinado, A. Niveleau, et al. A Mouse Skin Multistage Carcinogenesis Model Reflects the Aberrant DNA Methylation Patterns of Human Tumors Cancer Res., August 15, 2004; 64(16): 5527 - 5534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Akagi, K. Sasai, and H. Hanafusa Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation PNAS, November 11, 2003; 100(23): 13567 - 13572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Zoumpourlis, S. Solakidi, A. Papathoma, and D. Papaevangeliou Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis Carcinogenesis, July 1, 2003; 24(7): 1159 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-E. Murphy, R. E. Morales, J. Scott, and T. S. Kupper IL-1{alpha}, Innate Immunity, and Skin Carcinogenesis: The Effect of Constitutive Expression of IL-1{alpha} in Epidermis on Chemical Carcinogenesis J. Immunol., June 1, 2003; 170(11): 5697 - 5703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Goldman and P. G. Shields Food Mutagens J. Nutr., March 1, 2003; 133(3): 965S - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Singh, A. K. Tyagi, J. Zhao, and R. Agarwal Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis Carcinogenesis, March 1, 2002; 23(3): 499 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Stopper and W. K. Lutz Induction of micronuclei in human cell lines and primary cells by combination treatment with {gamma}-radiation and ethyl methanesulfonate Mutagenesis, March 1, 2002; 17(2): 177 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. McLean, K. Brown, M. I. Arbuckle, A. W. Wyke, T. Pikkarainen, E. Ruoslahti, and M. C. Frame Decreased Focal Adhesion Kinase Suppresses Papilloma Formation during Experimental Mouse Skin Carcinogenesis Cancer Res., December 1, 2001; 61(23): 8385 - 8389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hanausek, P. Ganesh, Z. Walaszek, C. J. Arntzen, T. J. Slaga, and J. U. Gutterman From the Cover: Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model PNAS, September 25, 2001; 98(20): 11551 - 11556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Rossiter, S. Beissert, C. Mayer, M. P. Schön, B. G. Wienrich, E. Tschachler, and T. S. Kupper Targeted Expression of bcl-2 to Murine Basal Epidermal Keratinocytes Results in Paradoxical Retardation of Ultraviolet- and Chemical-induced Tumorigenesis Cancer Res., May 1, 2001; 61(9): 3619 - 3626. [Abstract] [Full Text]
|
|
|
|
|
|
A. W. Lin and S. W. Lowe Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation PNAS, April 12, 2001; (2001) 91100298. [Abstract] [Full Text]
|
|
|
|
|
|
J. I. Goodman A Perspective on Current and Future Uses of Alternative Models for Carcinogenicity Testing Toxicol Pathol, January 1, 2001; 29(1_suppl): 173 - 176. [Abstract] [PDF]
|
|
|
|
|
|
A. W. Lin and S. W. Lowe Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation PNAS, April 24, 2001; 98(9): 5025 - 5030. [Abstract] [Full Text] [PDF]
|
|