Carcinogenesis, Vol. 21, No. 3, 485-495,
March 2000
© 2000 Oxford University Press
Cancer Biology |
Apoptosis in cancer
Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, New York, NY 11724, USA
In the last decade, basic cancer research has produced remarkable advances in our understanding of cancer biology and cancer genetics. Among the most important of these advances is the realization that apoptosis and the genes that control it have a profound effect on the malignant phenotype. For example, it is now clear that some oncogenic mutations disrupt apoptosis, leading to tumor initiation, progression or metastasis. Conversely, compelling evidence indicates that other oncogenic changes promote apoptosis, thereby producing selective pressure to override apoptosis during multistage carcinogenesis. Finally, it is now well documented that most cytotoxic anticancer agents induce apoptosis, raising the intriguing possibility that defects in apoptotic programs contribute to treatment failure. Because the same mutations that suppress apoptosis during tumor development also reduce treatment sensitivity, apoptosis provides a conceptual framework to link cancer genetics with cancer therapy. An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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E. L. Soucie, M. G. Annis, J. Sedivy, J. Filmus, B. Leber, D. W. Andrews, and L. Z. Penn Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria Mol. Cell. Biol., July 15, 2001; 21(14): 4725 - 4736. [Abstract] [Full Text] [PDF]
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M. V. Blagosklonny and A. B. Pardee Exploiting Cancer Cell Cycling for Selective Protection of Normal Cells Cancer Res., June 1, 2001; 61(11): 4301 - 4305. [Abstract] [Full Text] [PDF]
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L. Foghsgaard, D. Wissing, D. Mauch, U. Lademann, L. Bastholm, M. Boes, F. Elling, M. Leist, and M. Jaattela Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor J. Cell Biol., May 21, 2001; 153(5): 999 - 1010. [Abstract] [Full Text] [PDF]
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Y. P. Dragan, W. R. Bidlack, S. M. Cohen, T. L. Goldsworthy, G. C. Hard, P. C. Howard, R. T. Riley, and K. A. Voss Implications of Apoptosis for Toxicity, Carcinogenicity, and Risk Assessment: Fumonisin B1 as an Example Toxicol. Sci., May 1, 2001; 61(1): 6 - 17. [Abstract] [Full Text] [PDF]
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L. K. Leung and T. T. Wang Bcl-2 Is Not Reduced in the Death of MCF-7 Cells at Low Genistein Concentration J. Nutr., December 1, 2000; 130(12): 2922 - 2926. [Abstract] [Full Text] [PDF]
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 W. K. Hong, M. R. Spitz, and S. M. Lippman Cancer Chemoprevention in the 21st Century: Genetics, Risk Modeling, and Molecular Targets J. Clin. Oncol., November 1, 2000; 18(90001): 9s - 18. [Full Text] [PDF]
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I. Shureiqi, D. Chen, J. J. Lee, P. Yang, R. A. Newman, D. E. Brenner, R. Lotan, S. M. Fischer, and S. M. Lippman 15-LOX-1: a Novel Molecular Target of Nonsteroidal Anti-inflammatory Drug-Induced Apoptosis in Colorectal Cancer Cells J Natl Cancer Inst, July 19, 2000; 92(14): 1136 - 1142. [Abstract] [Full Text] [PDF]
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M. D. Vos, C. A. Ellis, A. Bell, M. J. Birrer, and G. J. Clark Ras Uses the Novel Tumor Suppressor RASSF1 as an Effector to Mediate Apoptosis J. Biol. Chem., November 10, 2000; 275(46): 35669 - 35672. [Abstract] [Full Text] [PDF]
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D. R. Mercatante, C. D. Bortner, J. A. Cidlowski, and R. Kole Modification of Alternative Splicing of Bcl-x Pre-mRNA in Prostate and Breast Cancer Cells. ANALYSIS OF APOPTOSIS AND CELL DEATH J. Biol. Chem., May 4, 2001; 276(19): 16411 - 16417. [Abstract] [Full Text] [PDF]
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X. W. Wang, A. Tseng, N. A. Ellis, E. A. Spillare, S. P. Linke, A. I. Robles, H. Seker, Q. Yang, P. Hu, S. Beresten, et al. Functional Interaction of p53 and BLM DNA Helicase in Apoptosis J. Biol. Chem., August 24, 2001; 276(35): 32948 - 32955. [Abstract] [Full Text] [PDF]
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P. Devarajan, M. De Leon, F. Talasazan, A. R. Schoenfeld, E. J. Davidowitz, and R. D. Burk The von Hippel-Lindau Gene Product Inhibits Renal Cell Apoptosis via Bcl-2-dependent Pathways J. Biol. Chem., October 26, 2001; 276(44): 40599 - 40605. [Abstract] [Full Text] [PDF]
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A. Bergsmedh, A. Szeles, M. Henriksson, A. Bratt, M. J. Folkman, A.-L. Spetz, and L. Holmgren Horizontal transfer of oncogenes by uptake of apoptotic bodies PNAS, May 22, 2001; 98(11): 6407 - 6411. [Abstract] [Full Text] [PDF]
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