Carcinogenesis, Vol. 21, No. 4, 617-621,
April 2000
© 2000 Oxford University Press
Molecular Epidemiology and Cancer Prevention |
Chemoprevention of familial adenomatous polyposis development in the APCmin mouse model by 1,4-phenylene bis(methylene)selenocyanate
Chemoprevention Program, Division of Nutritional Carcinogenesis and
1 Division of Cancer Etiology and Prevention, American Health Foundation, Valhalla, NY 10595, USA
Epidemiological and experimental studies have suggested that dietary supplementation with selenium can inhibit the development of cancers at several organ sites. We have consistently shown that 1,4-phenylene bis(methylene) selenocyanate (p-XSC) is a highly effective cancer chemopreventive agent against the development of chemically induced cancers in several laboratory animal species. This is the first report describing the preventive effects of p-XSC in an animal model of familial adenomatous polyposis (FAP) containing a germline mutation of the APC gene. Six-week old male (heterozygous) C57BL/6J-APCmin or wild-type mice were fed high fat diets containing 0, 10 or 20 p.p.m. p-XSC. After 80 days, the mice were killed and their intestines were excised and evaluated for polyps. Multiple samples were also harvested from normal appearing small intestine and colon for molecular analysis. Both the mucosa and polyps from the intestine and colon were assayed for ß-catenin, cyclooxygenase (COX)-2 expression and COX isoform activities. Administration of p-XSC in the diet significantly decreased the rate of formation of small intestinal tumors (P < 0.0001) and colon tumors (P < 0.002) in APCmin mice. p-XSC produced a dose-dependent inhibition of tumors in both small intestine (P < 0.0001) and colon (P < 0.035). Mice fed 20 p.p.m. p-XSC had significantly lower levels of ß-catenin expression and COX-2 activity in polyps. These observations demonstrate for the first time that the synthetic organoselenium compound p-XSC possesses antitumor activity against genetically predisposed neoplastic lesions, such as FAP. While the exact mechanism(s) for this antitumor activity of p-XSC remains to be elucidated, it appears that modulation of ß-catenin expression and COX-2 activity is associated with inhibition of intestinal polyps.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. V. Rao, M. V. Swamy, J. M.R. Patlolla, and L. Kopelovich Suppression of Familial Adenomatous Polyposis by CP-31398, a TP53 Modulator, in APCmin/+ Mice Cancer Res., September 15, 2008; 68(18): 7670 - 7675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. T. Kawasaki, E. M. Hurt, T. Mistree, and W. L. Farrar Targeting Cancer Stem Cells with Phytochemicals Mol. Interv., August 1, 2008; 8(4): 174 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-T. Hwang, Y. M. Kim, Y.-J. Surh, H. W. Baik, S.-K. Lee, J. Ha, and O. J. Park Selenium Regulates Cyclooxygenase-2 and Extracellular Signal-Regulated Kinase Signaling Pathways by Activating AMP-Activated Protein Kinase in Colon Cancer Cells. Cancer Res., October 15, 2006; 66(20): 10057 - 10063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Swamy, J. M.R. Patlolla, V. E. Steele, L. Kopelovich, B. S. Reddy, and C. V. Rao Chemoprevention of Familial Adenomatous Polyposis by Low Doses of Atorvastatin and Celecoxib Given Individually and in Combination to APCMin Mice. Cancer Res., July 15, 2006; 66(14): 7370 - 7377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Duffield-Lillico, I. Shureiqi, and S. M. Lippman Can Selenium Prevent Colorectal Cancer? A Signpost From Epidemiology J Natl Cancer Inst, November 17, 2004; 96(22): 1645 - 1647. [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Swamy, I. Cooma, J. M.R. Patlolla, B. Simi, B. S. Reddy, and C. V. Rao Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: Novel strategies for colon cancer prevention and treatment Mol. Cancer Ther., February 1, 2004; 3(2): 215 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Swamy, C. R. Herzog, and C. V. Rao Inhibition of COX-2 in Colon Cancer Cell Lines by Celecoxib Increases the Nuclear Localization of Active p53 Cancer Res., September 1, 2003; 63(17): 5239 - 5242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yamada and H. Mori Pre-cancerous lesions for colorectal cancers in rodents: a new concept Carcinogenesis, June 1, 2003; 24(6): 1015 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Corpet and F. Pierre Point: From Animal Models to Prevention of Colon Cancer. Systematic Review of Chemoprevention in Min Mice and Choice of the Model System Cancer Epidemiol. Biomarkers Prev., May 1, 2003; 12(5): 391 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Narayanan, N. K. Narayanan, B. Simi, and B. S. Reddy Modulation of Inducible Nitric Oxide Synthase and Related Proinflammatory Genes by the Omega-3 Fatty Acid Docosahexaenoic Acid in Human Colon Cancer Cells Cancer Res., March 1, 2003; 63(5): 972 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamada, K. Hata, Y. Hirose, A. Hara, S. Sugie, T. Kuno, N. Yoshimi, T. Tanaka, and H. Mori Microadenomatous Lesions Involving Loss of Apc Heterozygosity in the Colon of Adult ApcMin/+ Mice Cancer Res., November 15, 2002; 62(22): 6367 - 6370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-w. Jeong, M.-H. Yoo, T. S. Kim, J.-H. Kim, and I. Y. Kim Protection of Mice from Allergen-induced Asthma by Selenite. PREVENTION OF EOSINOPHIL INFILTRATION BY INHIBITION OF NF-kappa B ACTIVATION J. Biol. Chem., May 10, 2002; 277(20): 17871 - 17876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Davis, H. Zeng, and J. W. Finley Selenium-Enriched Broccoli Decreases Intestinal Tumorigenesis in Multiple Intestinal Neoplasia Mice J. Nutr., February 1, 2002; 132(2): 307 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Rao, C. Indranie, B. Simi, P. T. Manning, J. R. Connor, and B. S. Reddy Chemopreventive Properties of a Selective Inducible Nitric Oxide Synthase Inhibitor in Colon Carcinogenesis, Administered Alone or in Combination with Celecoxib, a Selective Cyclooxygenase-2 Inhibitor Cancer Res., January 1, 2002; 62(1): 165 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Rao, C-Q. Wang, B. Simi, J. G. Rodriguez, I. Cooma, K. El-Bayoumy, and B. S. Reddy Chemoprevention of Colon Cancer by a Glutathione Conjugate of 1,4-Phenylenebis(methylene)selenocyanate, a Novel Organoselenium Compound with Low Toxicity Cancer Res., May 1, 2001; 61(9): 3647 - 3652. [Abstract] [Full Text]
|
|
|
|
|
|
C. V. Rao, Y. Hirose, C. Indranie, and B. S. Reddy Modulation of Experimental Colon Tumorigenesis by Types and Amounts of Dietary Fatty Acids Cancer Res., March 1, 2001; 61(5): 1927 - 1933. [Abstract] [Full Text]
|
|
|
|
|
|
C. A. Blum, M. Xu, G. A. Orner, A. T. Fong, G. S. Bailey, G. D. Stoner, D. T. Horio, and R. H. Dashwood {beta}-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol Carcinogenesis, February 1, 2001; 22(2): 315 - 320. [Abstract] [Full Text] [PDF]
|
|