Carcinogenesis, Vol. 21, No. 5, 1007-1011,
May 2000
© 2000 Oxford University Press
Carcinogenesis |
Exploring the relationship between the inhibition of gap junctional intercellular communication and other biological phenomena
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
The mechanistic relationship of the inhibition of gap junctional intercellular communication (GJIC) to other toxicological phenomena was explored using a recently developed method that models the properties of a large population of molecules chosen to represent the `universe of chemicals'. The analyses indicate that inhibition of GJIC is strongly linked to the carcinogenic process in rodents, to cellular but not systemic toxicity, to biological phenomena that may involve inflammatory processes and to development effects. The inhibition of GJIC appears not to be associated with genotoxic mechanisms. With respect to cancer causation, integration of the analyses suggests that inhibition of GJIC is involved in non-genotoxic cancer induction or in the non-genotoxic phases of the carcinogenic process (such as inflammation, cell toxicity, cell proliferation, inhibition of cell differentiation and apoptosis).
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. C. M. Staal, D. S. Pushparajah, M. H. M. van Herwijnen, R. W. H. Gottschalk, L. M. Maas, C. Ioannides, F. J. van Schooten, and J. H. M. van Delft Interactions between polycyclic aromatic hydrocarbons in binary mixtures: Effects on gene expression and DNA adduct formation in precision-cut rat liver slices Mutagenesis, August 18, 2008; (2008) gen041v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Trosko and B. L. Upham The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment Mutagenesis, March 1, 2005; 20(2): 81 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Lee, H. J. Lee, Y.-J. Surh, and C. Y. Lee Vitamin C and cancer chemoprevention: reappraisal Am. J. Clinical Nutrition, December 1, 2003; 78(6): 1074 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Machala, L. Blaha, J. Vondracek, J. E. Trosko, J. Scott, and B. L. Upham Inhibition of Gap Junctional Intercellular Communication by Noncoplanar Polychlorinated Biphenyls: Inhibitory Potencies and Screening for Potential Mode(s) of Action Toxicol. Sci., November 1, 2003; 76(1): 102 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Leithe, V. Cruciani, T. Sanner, S.-O. Mikalsen, and E. Rivedal Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C Carcinogenesis, July 1, 2003; 24(7): 1239 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Warner, M. J. Fernstrom, and R. J. Ruch Inhibition of Mouse Hepatocyte Gap Junctional Intercellular Communication by Phenobarbital Correlates with Strain-Specific Hepatocarcinogenesis Toxicol. Sci., February 1, 2003; 71(2): 190 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Koval Sharing signals: connecting lung epithelial cells with gap junction channels Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L875 - L893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Hu, P. D. Jones, B. L. Upham, J. E. Trosko, C. Lau, and J. P. Giesy Inhibition of Gap Junctional Intercellular Communication by Perfluorinated Compounds in Rat Liver and Dolphin Kidney Epithelial Cell Lines in Vitro and Sprague-Dawley Rats in Vivo Toxicol. Sci., August 1, 2002; 68(2): 429 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Blaha, P. Kapplova, J. Vondracek, B. Upham, and M. Machala Inhibition of Gap-Junctional Intercellular Communication by Environmentally Occurring Polycyclic Aromatic Hydrocarbons Toxicol. Sci., January 1, 2002; 65(1): 43 - 51. [Abstract] [Full Text] [PDF]
|
|