Carcinogenesis, Vol. 21, No. 5, 909-914,
May 2000
© 2000 Oxford University Press
Cancer Biology |
Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice
1 Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 and
2 Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Apoptosis, or regulated cell suicide, eliminates unwanted and damaged cells, including precancerous and cancerous cells. Since reactive oxygen species (ROS) act as essential apoptotic mediators, we reasoned that increasing the ROS level might enhance apoptosis and thereby slow down tumor growth. Here, using a defined transgenic brain tumor model with known tumor apoptosis rates, we test the impact of antioxidant-depleted diet, capable of increasing ROS levels, or antioxidant-enriched diets on tumor growth. Dramatically increased apoptosis occurs within tumors, but not in normal tissues of antioxidant-depleted mice. The presence of detectable increased oxidant stress within tumors indicates that the likely mechanism of enhanced tumor apoptosis is via ROS and DNA oxidative impairment. Importantly, due to the ROS-enhanced apoptosis, tumor growth is inhibited in mice fed an antioxidant-depleted diet. In clear contrast, an antioxidant-rich diet had no impact on tumor growth.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Halder, U. Bhattacharya, S. Mukhopadhyay, and A. K. Giri Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade Carcinogenesis, January 1, 2008; 29(1): 129 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Qanungo, M. Das, S. Haldar, and A. Basu Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells Carcinogenesis, May 1, 2005; 26(5): 958 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. N. Prasad Multiple Dietary Antioxidants Enhance the Efficacy of Standard and Experimental Cancer Therapies and Decrease Their Toxicity Integr Cancer Ther, December 1, 2004; 3(4): 310 - 322. [Abstract] [PDF]
|
|
|
|
 |
|
 S. H. Zeisel Antioxidants Suppress Apoptosis J. Nutr., November 1, 2004; 134(11): 3179S - 3180S. [Full Text] [PDF]
|
|
|
|
|
|
U. Wenzel, A. Nickel, S. Kuntz, and H. Daniel Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions Carcinogenesis, May 1, 2004; 25(5): 703 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Albright, R. I. Salganik, and T. Van Dyke Dietary Depletion of Vitamin E and Vitamin A Inhibits Mammary Tumor Growth and Metastasis in Transgenic Mice J. Nutr., May 1, 2004; 134(5): 1139 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Norman, R. R. Butrum, E. Feldman, D. Heber, D. Nixon, M. F. Picciano, R. Rivlin, A. Simopoulos, M. J. Wargovich, E. K. Weisburger, et al. The Role of Dietary Supplements during Cancer Therapy J. Nutr., November 1, 2003; 133(11): 3794S - 3799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Connelly, J. Satia-Abouta, C. F. Martin, T. O. Keku, J. T. Woosley, P. K. Lund, and R. S. Sandler Vitamin C Intake and Apoptosis in Normal Rectal Epithelium Cancer Epidemiol. Biomarkers Prev., June 1, 2003; 12(6): 559 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Hong, R. S. Chapkin, R. Barhoumi, R. C. Burghardt, N. D. Turner, C. E. Henderson, L. M. Sanders, Y.-Y. Fan, L. A. Davidson, M. E. Murphy, et al. Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes Carcinogenesis, November 1, 2002; 23(11): 1919 - 1926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K R Martin and J C Barrett Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity Human and Experimental Toxicology, February 1, 2002; 21(2): 71 - 75. [Abstract] [PDF]
|
|
|
|
 |
|
 R. I. Salganik The Benefits and Hazards of Antioxidants: Controlling Apoptosis and Other Protective Mechanisms in Cancer Patients and the Human Population J. Am. Coll. Nutr., October 1, 2001; 20(90005): 464S - 472. [Abstract] [Full Text]
|
|
|
|
|
|
K. R. Martin, C. Trempus, M. Saulnier, F. W. Kari, J.C. Barrett, and J. E. French Dietary N-acetyl-L-cysteine modulates benzo[a]pyrene-induced skin tumors in cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) mice Carcinogenesis, September 1, 2001; 22(9): 1373 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H Zeisel Is there a metabolic basis for dietary supplementation? Am. J. Clinical Nutrition, August 1, 2000; 72(2): 507S - 511. [Abstract] [Full Text] [PDF]
|
|