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Carcinogenesis, Vol. 22, No. 3, 507-513, March 2001
© 2001 Oxford University Press

CARCINOGENESIS

Rat gap junction connexin-30 inhibits proliferation of glioma cell lines

Frédéric Princen1, Pierre Robe1,,2,,3, Daniel Gros4, Thérèse Jarry-Guichard4, Jacques Gielen1, Marie-Paule Merville1 and Vincent Bours1,,5

1 Laboratory of Medical Chemistry and Medical Oncology,
2 Department of Human Physiology and
3 Department of Neurosurgery, University of Liège, Sart-Tilman, 4000 Liège, Belgium,
4 Laboratoire de Génétique et Physiologie du Développement (UMR 6545), and Institut de Biologie du Développement de Marseille (IBDM), Université de la Méditerranée, Marseille, France

Connexins, the structural components of gap junctions, control cell growth and differentiation and are believed to belong to a family of tumour suppressor genes. Studies on connexin localization in brain showed that several of these proteins were expressed in distinct compartments of the brain in a cell-type specific manner, indicating that different gap junctions play specific roles in the physiology of the mammalian brain. In this report, we first cloned rat connexin-30 cDNA from brain and showed that it was expressed in long-term primary culture of rat astrocytes. In order to examine the potential role of connexin-30 in tumour cell proliferation, we transfected the connexin-30 cDNA into two rat glioma cell lines (9L and C6) which have lost its expression. Transfected clones adequately expressed membrane-bound connexin-30 protein. Connexin-30-expressing clones showed slower growth, lower DNA synthesis and reduced proliferation in soft agar as compared with the parental and control cells. We concluded that connexin-30 may also probably be considered as a tumour suppressor in rat gliomas.


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