Carcinogenesis, Vol. 22, No. 5, 827-829,
May 2001
© 2001 Oxford University Press
SHORT COMMUNICATION |
Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk
Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki,
1 Department of Oncology,
2 Department of Surgery,
3 Department of Clinical Pathology and Forensic Medicine and
5 Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland and
4 Unit of Cancer Epidemiology (INSERM U521), Gustave-Roussy Institute, Villejuif, France
Superoxide dismutases play a key role in the detoxification of superoxide radicals and thus protect cells from damage induced by free radicals. Within mitochondria manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species. Polymorphism in the mitochondrial targeting sequence of MnSOD has recently been associated with risk of breast cancer. We examined this in a study population consisting of 483 breast cancer cases and 482 controls, all of Finnish Caucasian origin. Odds ratios (OR) and 95% confidence intervals (95% CIs) were estimated by unconditional logistic regression. MnSOD genotypes containing the variant A allele were found to be associated with a 1.5-fold (95% CI 1.1–2.0) increased risk of breast cancer compared with those with the homozygous wild-type genotype (MnSOD VV). This finding supports the proposal that MnSOD genotypes may modify individual breast cancer risk.
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