Carcinogenesis, Vol. 22, No. 6, 885-890,
June 2001
© 2001 Oxford University Press
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION |
Inverse correlation between alcohol consumption and lymphocyte levels of 8-hydroxydeoxyguanosine in humans
International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, Cedex 08, France,
1 Deutsches Institut für Ernährungsforschung, Arthur Scheunert Allee 114-116, 14558 Potsdam-Rehbrücke, Germany,
2 Servizio di Epidemiologia dei Tumori, Via Santena 7, 10126 Turin, Italy,
3 Granada Cancer Registry, Escuela Andaluza de Salud Publica, E-18080 Granada, Spain and
4 Department of Community Medicine, Lund University, Malmö University Hospital, S-20502 Malmö, Sweden
In a cross-sectional study of 115 premenopausal non-smoking women, we examined the relationship between lymphocyte levels of 8-hydroxy-2'-deoxyguanosine (8-oxodGuo) and habitual alcohol consumption. The study was conducted in four different regions of Europe, including Potsdam (Germany), Turin (Italy), Malmö (Sweden) and Granada (Spain). Mean 8-oxodGuo levels differed significantly across study centres (P = 0.001), with the highest levels in Granada [2.17 8-oxodGuox10–6 2'-deoxyguanosine (95% confidence interval 1.27–4.40)] and lowest levels in Turin [1.19 (0.36–4.29)]. Mean levels of total alcohol intake and of types of alcoholic beverages consumed (wine, fortified wines, beer and cider) also differed across the study centres (P < 0.05), with the highest total alcohol consumption in Turin, and the lowest intake in Granada. When combining all the data, but adjusting for study centre, individual 8-oxodGuo level correlated inversely with alcohol intake. This inverse association remained unaltered after further adjustment for Quetelet Index, fruit and vegetable consumption, and plasma carotenoid levels. Furthermore, the inverse association was also observed for each of the study centres separately, and for different beverage types, with the exception of Granada, where the majority of women were non-drinkers and where alcohol intakes were also very low for the consumers. Finally, on a group level, mean levels of 8-oxodGuo and alcohol intake were also inversely associated between the four study centres. The finding of a relationship between alcohol consumption and 8-oxodGuo in lymphocytes was unexpected and not based on a prior hypothesis. This finding consequently requires confirmation from a randomized intervention study.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Rohrmann, J. Linseisen, T. J. Key, M. K. Jensen, K. Overvad, N. F. Johnsen, A. Tjonneland, R. Kaaks, M. M. Bergmann, C. Weikert, et al. Alcohol Consumption and the Risk for Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1282 - 1287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rohrmann, J. Linseisen, H. C. Boshuizen, J. Whittaker, A. Agudo, P. Vineis, P. Boffetta, M. K. Jensen, A. Olsen, K. Overvad, et al. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Am. J. Epidemiol., December 1, 2006; 164(11): 1103 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mahabir, M. F. Leitzmann, M. J. Virtanen, J. Virtamo, P. Pietinen, D. Albanes, and P. R. Taylor Prospective Study of Alcohol Drinking and Renal Cell Cancer Risk in a Cohort of Finnish Male Smokers Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 170 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. De Bont and N. van Larebeke Endogenous DNA damage in humans: a review of quantitative data Mutagenesis, May 1, 2004; 19(3): 169 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Greenrod and M. Fenech The principal phenolic and alcoholic components of wine protect human lymphocytes against hydrogen peroxide- and ionizing radiation-induced DNA damage in vitro Mutagenesis, March 1, 2003; 18(2): 119 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Comparative analysis of baseline 8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different methods in different laboratories: an approach to consensus Carcinogenesis, December 1, 2002; 23(12): 2129 - 2133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Giovannelli, C. Saieva, G. Masala, G. Testa, S. Salvini, V. Pitozzi, E. Riboli, P. Dolara, and D. Palli Nutritional and lifestyle determinants of DNA oxidative damage: a study in a Mediterranean population Carcinogenesis, September 1, 2002; 23(9): 1483 - 1489. [Abstract] [Full Text] [PDF]
|
|