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Carcinogenesis, Vol. 23, No. 11, 1777-1780, November 2002
© 2002 Oxford University Press

COMMENTARY

Migrating colonic crypt epithelial cells: primary targets for transformation

Sergio A. Lamprecht1 and Martin Lipkin

Strang Cancer Research Laboratory at the Rockerfeller University, 1230 York Avenue, New York, NY 10021, USA

It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.


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