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Carcinogenesis, Vol. 23, No. 11, 1961-1962, November 2002
© 2002 Oxford University Press


LETTER TO THE EDITOR

Redox-regulated mechanism may account for zerumbone’s ability to suppress cancer-cell proliferation.

A. Hoffman1, L. M. Spetner1 and M. Burke2

1 Rehovot Research Associates, Rehovot, Israel and
2 Tel Aviv University Sackler Medical School, Tel Aviv, Israel

Abstract

A recent report shows that zerumbone (ZER) inhibits the proliferation of, and induces apoptosis in, colon cancer cells. We suggest a mechanism for these phenomena, based on our recently proposed redox model of cell proliferation which stresses the importance of intracellular redox potential E in the control of proliferation of normal and cancer cells.


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