Carcinogenesis, Vol. 23, No. 11, 1961-1962,
November 2002
© 2002 Oxford University Press
LETTER TO THE EDITOR |
Redox-regulated mechanism may account for zerumbones ability to suppress cancer-cell proliferation.
1 Rehovot Research Associates, Rehovot, Israel and
2 Tel Aviv University Sackler Medical School, Tel Aviv, Israel
Abstract
A recent report shows that zerumbone (ZER) inhibits the proliferation of, and induces apoptosis in, colon cancer cells. We suggest a mechanism for these phenomena, based on our recently proposed redox model of cell proliferation which stresses the importance of intracellular redox potential E in the control of proliferation of normal and cancer cells.