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Carcinogenesis Advance Access originally published online on August 14, 2003
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Carcinogenesis, Vol. 24, No. 11, 1819-1826, November 2003
© 2003 Oxford University Press

CARCINOGENESIS

Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice

Manuela Gariboldi1,2, Monica Spinola1, Silvano Milani3, Carmen Pignatiello1, Koji Kadota2,4, Hidemasa Bono2, Yoshihide Hayashizaki2, Tommaso A. Dragani1,5 and Yasushi Okazaki2,5

1 Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy, 2 Laboratory for Genome Exploration Research Group, RIKEN, Yokohama, Japan, 3 Institute of Medical Statistics and Biometry, University of Milan, Milan, Italy and 4 University of Tokyo, Tokyo, Japan

Genetic susceptibility to lung tumorigenesis shows large variations among mouse strains. To test whether genetic predisposition to lung tumorigenesis is associated with a specific gene expression profile in normal lungs, we analyzed gene expression in 16 inbred strains of known susceptibility/resistance to lung tumorigenesis, using the RIKEN mouse full-length cDNA 19K microarray set. The strain-specific expression profile of 91 cDNA clones correlated with strain lung tumor susceptibility/resistance and predicted, by principal component analysis, the genetic predisposition to lung tumorigenesis in mice.


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