Carcinogenesis, Vol. 24, No. 2, 155-157,
February 2003
© 2003 Oxford University Press
COMMENTARY |
The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications
Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555 and
1 Division of Cancer Biology, Emory University, Atlanta, GA 30335, USA
Oxidatively damaged bases in the genome are likely to be responsible for mutations leading to sporadic carcinogenesis. Two structurally similar DNA glycosylases, NTH1 and OGG1, which are able to excise most of these damaged bases, were identified previously in mammalian cells. A distinct family, consisting of two human DNA glycosylases orthologous to enzymes in Escherichia coli, has recently been characterized; they have overlapping substrate ranges with NTH1 and OGG1. The presence of multiple enzymes with potential back-up functions underscores the importance of removing both endogenously and exogenously generated oxidatively damaged bases from the genome, and may explain why no cancer or other disease phenotype has so far been linked to the deficiency of a single DNA glycosylase.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A R Dallosso, S Dolwani, N Jones, S Jones, J Colley, J Maynard, S Idziaszczyk, V Humphreys, J Arnold, A Donaldson, et al. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3 Gut, September 1, 2008; 57(9): 1252 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Tolentino, T. J. Burke, S. Mukhopadhyay, W. G. McGregor, and A. K. Basu Inhibition of DNA replication fork progression and mutagenic potential of 1, N6-ethenoadenine and 8-oxoguanine in human cell extracts Nucleic Acids Res., March 27, 2008; 36(4): 1300 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lu, S. Yadav, P. G. Shah, T. Liu, B. Tian, S. Pukszta, N. Villaluna, E. Kutejova, C. S. Newlon, J. H. Santos, et al. Roles for the Human ATP-dependent Lon Protease in Mitochondrial DNA Maintenance J. Biol. Chem., June 15, 2007; 282(24): 17363 - 17374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mao, X. Pan, B.-B. Zhu, Y. Zhang, F. Yuan, J. Huang, M. A. Lovell, M. P. Lee, W. R. Markesbery, G.-M. Li, et al. Identification and characterization of OGG1 mutations in patients with Alzheimer's disease Nucleic Acids Res., April 10, 2007; (2007) gkm189v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Das, T. K. Hazra, I. Boldogh, S. Mitra, and K. K. Bhakat Induction of the Human Oxidized Base-specific DNA Glycosylase NEIL1 by Reactive Oxygen Species J. Biol. Chem., October 21, 2005; 280(42): 35272 - 35280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Sartori, G. M. Lingaraju, P. Hunziker, F. K. Winkler, and J. Jiricny Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases Nucleic Acids Res., December 16, 2004; 32(22): 6531 - 6539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Thompson DNA Oxidation Products, Antioxidant Status, and Cancer Prevention J. Nutr., November 1, 2004; 134(11): 3186S - 3187S. [Full Text] [PDF]
|
|
|
|
|
|
M. Matsubara, T. Tanaka, H. Terato, E. Ohmae, S. Izumi, K. Katayanagi, and H. Ide Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase Nucleic Acids Res., October 5, 2004; 32(17): 5291 - 5302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Russo, G. De Luca, P. Degan, E. Parlanti, E. Dogliotti, D. E. Barnes, T. Lindahl, H. Yang, J. H. Miller, and M. Bignami Accumulation of the Oxidative Base Lesion 8-Hydroxyguanine in DNA of Tumor-Prone Mice Defective in Both the Myh and Ogg1 DNA Glycosylases Cancer Res., July 1, 2004; 64(13): 4411 - 4414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. O. Alekseyev, M. L. Hamm, and J. M. Essigmann Aflatoxin B1 formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo Carcinogenesis, June 1, 2004; 25(6): 1045 - 1051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Fromme and G. L. Verdine DNA Lesion Recognition by the Bacterial Repair Enzyme MutM J. Biol. Chem., December 19, 2003; 278(51): 51543 - 51548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Paz-Elizur, M. Krupsky, S. Blumenstein, D. Elinger, E. Schechtman, and Z. Livneh DNA Repair Activity for Oxidative Damage and Risk of Lung Cancer J Natl Cancer Inst, September 3, 2003; 95(17): 1312 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Cheadle, S. Dolwani, and J. R. Sampson Inherited defects in the DNA glycosylase MYH cause multiple colorectal adenoma and carcinoma Carcinogenesis, July 1, 2003; 24(7): 1281 - 1282. [Full Text] [PDF]
|
|