Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow A corrigendum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (26)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Zheng, Y.-L.
Right arrow Articles by Shields, P. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zheng, Y.-L.
Right arrow Articles by Shields, P. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Carcinogenesis, Vol. 24, No. 2, 269-274, February 2003
© 2003 Oxford University Press

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls

Yun-Ling Zheng1, Christopher A. Loffredo2, Zhipeng Yu1, Raymond T. Jones3, Mark J. Krasna3, Anthony J. Alberg4, Rex Yung4, Donna Perlmutter3, Lindsey Enewold2, Curtis C. Harris1 and Peter G. Shields2,5

1 Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland,
2 Cancer Genetics and Epidemiology Program, Lombardi Cancer Center, Georgetown University, Research Building W315, 3970 Reservoir Road, NW Washington, DC 20007,
3 Greenebaum Cancer Center, Department of Pathology and Surgery, University of Maryland School of Medicine, Baltimore, Maryland and
4 Department of Epidemiology and Pulmonary Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

Environmental exposure to carcinogens and individual susceptibility play significant roles in cancer risk. Suboptimal DNA repair capability, measured by quantifying mutagen-induced chromosome breaks, might explain variable host susceptibility to environmental carcinogens. In an ongoing lung cancer case-control study, we compared individual sensitivity to bleomycin-induced chromosome breaks in 152 non-small cell lung cancer patients with 94 population controls and 85 hospital controls with no history of cancer. Mutagen sensitivity was measured by mean number of chromatid breaks per cell in cultured peripheral blood lymphocytes treated with bleomycin. Non-parametric tests and {chi}2 tests were used to determine the statistical significance of the crude case-control comparisons, followed by logistic regression to adjust for important covariates. The mean number of bleomycin-induced breaks per cell was 1.01 for the cases compared with 0.86 for hospital controls (P < 0.01) and 0.89 for population controls (P < 0.01). The mean number of breaks per cell was 1.01 for those >65 years old and 0.81 for those <=65 years old (P < 0.01) among population controls. Defining bleomycin sensitive as >0.84 break/cell (the median level in population controls), 67% of the cases were bleomycin sensitive compared with 49% of the hospital controls [adjusted odds ratio (OR) = 2.69, 95% confidence interval (CI) = 1.44, 5.04], and 51% of the population controls (adjusted OR = 2.18, 95% CI = 1.13, 4.21). Our data indicate that the increased number of bleomycin-induced chromosome breaks was significantly associated with an increased risk of lung cancer in the first 331 subjects.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JCOHome page
X. Wu, J. Lin, H. B. Grossman, M. Huang, J. Gu, C. J. Etzel, C. I. Amos, C. P. Dinney, and M. R. Spitz
Projecting Individualized Probabilities of Developing Bladder Cancer in White Individuals
J. Clin. Oncol., November 1, 2007; 25(31): 4974 - 4981.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. R. Pine, L. E. Mechanic, S. Ambs, E. D. Bowman, S. J. Chanock, C. Loffredo, P. G. Shields, and C. C. Harris
Lung Cancer Survival and Functional Polymorphisms in MBL2, an Innate-Immunity Gene
J Natl Cancer Inst, September 19, 2007; 99(18): 1401 - 1409.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. J. Alberg, J. G. Ford, and J. M. Samet
Epidemiology of Lung Cancer: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Chest, September 1, 2007; 132(3_suppl): 29S - 55S.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. E. Mechanic, E. D. Bowman, J. A. Welsh, M. A. Khan, N. Hagiwara, L. Enewold, P. G. Shields, L. Burdette, S. Chanock, and C. C. Harris
Common Genetic Variation in TP53 Is Associated with Lung Cancer Risk and Prognosis in African Americans and Somatic Mutations in Lung Tumors
Cancer Epidemiol. Biomarkers Prev., February 1, 2007; 16(2): 214 - 222.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
D. L. Chao, C. C. Maley, X. Wu, D. C. Farrow, P. C. Galipeau, C. A. Sanchez, T. G. Paulson, P. S. Rabinovitch, B. J. Reid, M. R. Spitz, et al.
Mutagen Sensitivity and Neoplastic Progression in Patients with Barrett's Esophagus: A Prospective Analysis.
Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1935 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Hagiwara, L. E. Mechanic, G. E. Trivers, H. L. Cawley, M. Taga, E. D. Bowman, K. Kumamoto, P. He, M. Bernard, S. Doja, et al.
Quantitative Detection of p53 Mutations in Plasma DNA from Tobacco Smokers
Cancer Res., August 15, 2006; 66(16): 8309 - 8317.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. R. Pine, L. E. Mechanic, E. D. Bowman, J. A. Welsh, S. C. Chanock, P. G. Shields, and C. C. Harris
MDM2 SNP309 and SNP354 Are Not Associated with Lung Cancer Risk.
Cancer Epidemiol. Biomarkers Prev., August 1, 2006; 15(8): 1559 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
E. Erdei, S.-J. Lee, Q. Wei, L.-E. Wang, Y.-S. Song, D. Bovbjerg, and M. Berwick
Reliability of mutagen sensitivity assay: an inter-laboratory comparison
Mutagenesis, July 1, 2006; 21(4): 261 - 264.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
T. G. Natarajan, N. Ganesan, P. Carter-Nolan, C. A. Tucker, P. G. Shields, and L. L. Adams-Campbell
{gamma}-Radiation-Induced Chromosomal Mutagen Sensitivity Is Associated with Breast Cancer Risk in African-American Women: Caffeine Modulates the Outcome of Mutagen Sensitivity Assay.
Cancer Epidemiol. Biomarkers Prev., March 1, 2006; 15(3): 437 - 442.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
J. Cloos, W. P.H. de Boer, M. H.J. Snel, P. van den IJssel, B. Ylstra, C. R. Leemans, R. H. Brakenhoff, and B. J.M. Braakhuis
Microarray Analysis of Bleomycin-Exposed Lymphoblastoid Cells for Identifying Cancer Susceptibility Genes
Mol. Cancer Res., February 1, 2006; 4(2): 71 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y.-L. Zheng, C. A. Loffredo, A. J. Alberg, Z. Yu, R. T. Jones, D. Perlmutter, L. Enewold, M. J. Krasna, R. Yung, P. G. Shields, et al.
Less Efficient G2-M Checkpoint Is Associated with an Increased Risk of Lung Cancer in African Americans
Cancer Res., October 15, 2005; 65(20): 9566 - 9573.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Ewart-Toland, Q. Dai, Y.-T. Gao, H. Nagase, M. G. Dunlop, S. M. Farrington, R. A. Barnetson, H. Anton-Culver, D. Peel, A. Ziogas, et al.
Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types
Carcinogenesis, August 1, 2005; 26(8): 1368 - 1373.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
Z. Wei, J. Lifen, H. Jiliang, L. Jianlin, W. Baohong, and D. Hongping
Detecting DNA repair capacity of peripheral lymphocytes from cancer patients with UVC challenge test and bleomycin challenge test
Mutagenesis, July 1, 2005; 20(4): 271 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Y. Chang, R. Komaki, R. Sasaki, Z. Liao, C. W. Stevens, C. Lu, F. V. Fossella, P. K. Allen, J. D. Cox, M. R. Spitz, et al.
High Mutagen Sensitivity in Peripheral Blood Lymphocytes Predicts Poor Overall and Disease-Specific Survival in Patients with Stage III Non-Small Cell Lung Cancer Treated with Radiotherapy and Chemotherapy
Clin. Cancer Res., April 15, 2005; 11(8): 2894 - 2898.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
N. Caporaso
The Molecular Epidemiology of Oxidative Damage to DNA and Cancer
J Natl Cancer Inst, September 3, 2003; 95(17): 1263 - 1265.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.